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Rabbit Polyclonal ART3 Antibody

  • 中文名: ART3抗体
  • 别    名: Ecto-ADP-ribosyltransferase 3, ADP-ribosyltransferase C2 and C3 toxin-like 3, ARTC3, Mono(ADP-ribosyl)transferase 3, NAD(P)(+)--arginine ADP-ribosyltransferase 3, ART3, TMART
货号: IPDX34039
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000-1/4000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEcto-ADP-ribosyltransferase 3, ADP-ribosyltransferase C2 and C3 toxin-like 3, ARTC3, Mono(ADP-ribosyl)transferase 3, NAD(P)(+)--arginine ADP-ribosyltransferase 3, ART3, TMART
Entrez GeneID419
WB Predicted band size43.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ART3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-310 amino acids from the C-terminal region of human ART3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ART3抗体的参考文献示例(注:由于文献检索限制,以下内容基于领域知识模拟,建议通过学术数据库验证具体信息):

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1. **文献名称**:*Characterization of ART3 as a novel mono-ADP-ribosyltransferase in human tissues*

**作者**:Hara N, et al.

**摘要**:本研究首次克隆并鉴定了人源ART3的cDNA,发现其在睾丸和前列腺中高表达。通过特异性抗体检测,证实ART3蛋白定位于细胞质膜,并证实其具有单ADP-核糖基转移酶活性,可能参与G蛋白信号调控。

2. **文献名称**:*ART3 expression correlates with prostate cancer progression and androgen receptor signaling*

**作者**:Kleist B, et al.

**摘要**:利用ART3特异性抗体进行免疫组化分析,发现ART3在前列腺癌组织中过表达,并与雄激素受体(AR)通路激活相关。敲低ART3可抑制癌细胞增殖,提示其作为潜在治疗靶点。

3. **文献名称**:*ADP-ribosyltransferase 3 modulates DNA damage response via interaction with PARP1*

**作者**:Smith J, et al.

**摘要**:通过免疫共沉淀(使用ART3抗体)和共聚焦显微术,发现ART3与PARP1在DNA损伤修复中相互作用,可能通过调节PARylation影响基因组稳定性。

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**注意**:以上文献信息为示例性质,具体研究需以实际检索结果为准。建议通过PubMed或Google Scholar以“ART3 antibody”或“ADPRT3”为关键词查找最新文献。

背景信息

ART3 (ADP-ribosyltransferase 3) is a member of the ADP-ribosyltransferase family, enzymes that catalyze the transfer of ADP-ribose groups to target proteins, modulating their function. Unlike other ART family members (e.g., ART1 or ART2), ART3 is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage and exhibits tissue-specific expression, notably in testis, brain, and certain cancers. Its biological role remains less defined, though studies suggest involvement in cell signaling, differentiation, and cancer progression. ART3 antibodies are critical tools for detecting and studying the protein's expression, localization, and interaction networks. They enable applications like immunohistochemistry, Western blotting, and flow cytometry, aiding research into ART3's potential as a biomarker or therapeutic target in diseases such as prostate cancer or neurological disorders. Commercial ART3 antibodies are typically raised against specific epitopes (e.g., human ART3 peptide sequences) and validated for specificity across experimental models. Ongoing research aims to clarify its substrates, regulatory mechanisms, and pathophysiological relevance, positioning ART3 antibodies as essential reagents for unraveling its enigmatic roles in health and disease. (Word count: 198)

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