| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uridine phosphorylase 1, UPase 1, UrdPase 1, 2.4.2.3, UPP1, UP |
| Entrez GeneID | 7378 |
| WB Predicted band size | 33.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This UPP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 205-237 amino acids from human UPP1. |
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以下是关于UPP1抗体的3篇参考文献概览(基于公开信息整理，非真实文献，仅供示例参考)：
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1. **文献名称**: *"UPP1 as a Novel Biomarker in Colorectal Cancer: Immunohistochemical Analysis Using a Specific Polyclonal Antibody"*
**作者**: Zhang L, et al.
**摘要**: 本研究开发了一种针对UPP1蛋白的多克隆抗体，并通过免疫组化技术验证其在结直肠癌组织中的高表达。结果表明，UPP1表达水平与患者预后不良相关，提示其作为潜在治疗靶点的价值。
2. **文献名称**: *"Development of a Monoclonal Antibody for Detecting Uridine Phosphorylase 1 in Pancreatic Cancer Models"*
**作者**: Smith J, et al.
**摘要**: 该研究报道了一种高特异性的UPP1单克隆抗体的制备，并应用于胰腺癌细胞系和小鼠模型的蛋白表达检测。实验显示UPP1在肿瘤微环境中的代谢重编程中起关键作用。
3. **文献名称**: *"UPP1 Antibody-Based Flow Cytometry Reveals Its Role in T Cell Activation and Autoimmunity"*
**作者**: Tanaka K, et al.
**摘要**: 通过流式细胞术结合UPP1抗体，研究发现UPP1在活化的T淋巴细胞中表达上调，并参与调控嘧啶代谢通路，可能成为自身免疫性疾病的新型生物标志物。
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如需获取真实文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词“UPP1 antibody”或“uridine phosphorylase 1 antibody”。
The UPP1 (Uridine Phosphorylase 1) antibody is a tool used to study the enzyme uridine phosphorylase, which plays a critical role in pyrimidine metabolism. UPP1 catalyzes the reversible phosphorylation of uridine to uracil and ribose-1-phosphate, regulating nucleotide salvage pathways and influencing cellular proliferation. It is highly expressed in certain tissues, such as the liver and placenta, and is upregulated in pathological conditions, including cancers (e.g., colorectal, pancreatic) and inflammatory states, where it supports rapid cell growth by recycling nucleotides.
Research using UPP1 antibodies focuses on understanding its role in tumor progression, drug metabolism (e.g., activation of 5-fluorouracil chemotherapeutics), and immune modulation. These antibodies enable detection of UPP1 expression via techniques like Western blotting, immunohistochemistry, and ELISA, aiding in biomarker discovery and therapeutic targeting. Studies also explore UPP1's involvement in metabolic disorders and viral replication mechanisms.
Commercial UPP1 antibodies are typically raised against specific epitopes, with validation in model organisms and human samples. Their application spans basic research, diagnostic assays, and drug development, highlighting UPP1's dual role as a metabolic enzyme and a potential therapeutic target in oncology and inflammatory diseases.
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