| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ankyrin repeat and SAM domain-containing protein 1A, Odin, ANKS1A, ANKS1, KIAA0229, ODIN |
| Entrez GeneID | 23294 |
| WB Predicted band size | 123.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ANKS1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-319 amino acids from the N-terminal region of human ANKS1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于**ANKS1A (N-term)抗体**的示例参考文献(注：以下文献信息为示例性概括，具体文献需通过学术数据库核实)：
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1. **文献名称**：*ANKS1A regulates cell adhesion and migration via its N-terminal domain*
**作者**：Smith J, et al.
**摘要**：研究通过N-term抗体进行Western blot和免疫荧光分析，发现ANKS1A通过其N端结构域与膜蛋白相互作用，调控细胞黏附和迁移，提示其在肿瘤转移中的潜在作用。
2. **文献名称**：*ANKS1A interacts with the EGFR signaling pathway in lung cancer*
**作者**：Chen L, et al.
**摘要**：利用ANKS1A (N-term)抗体进行免疫共沉淀实验，发现ANKS1A通过N端区域与EGFR结合，增强下游信号传导，可能成为肺癌治疗的靶点。
3. **文献名称**：*ANKS1A expression in neuronal development and synaptic plasticity*
**作者**：Wang Y, et al.
**摘要**：通过N-term抗体在小鼠脑组织中的免疫组化分析，揭示ANKS1A在神经元突触形成和可塑性中的表达模式，提示其参与神经系统发育。
4. **文献名称**：*Proteomic profiling identifies ANKS1A as a novel biomarker in colorectal cancer*
**作者**：Garcia R, et al.
**摘要**：使用ANKS1A (N-term)抗体对结直肠癌组织进行高通量蛋白质组学分析，发现其表达水平与肿瘤分期和患者预后显著相关。
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建议通过**PubMed**或**Google Scholar**检索关键词“ANKS1A antibody”或“ANKS1A N-terminal”获取具体文献。
The ANKS1A (N-term) antibody is a reagent designed to target the N-terminal region of the Ankyrin Repeat and SAM Domain-Containing Protein 1A (ANKS1A), a multidomain scaffolding protein involved in diverse cellular processes. ANKS1A contains ankyrin repeats and a sterile alpha motif (SAM), which mediate protein-protein interactions critical for signaling pathways, cytoskeletal organization, and receptor tyrosine kinase (RTK) regulation. It plays roles in neuronal development, endocytosis, and intracellular trafficking, and has been implicated in diseases such as cancer and neurological disorders.
This antibody is commonly used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to detect ANKS1A expression and localization. Targeting the N-terminal region ensures specificity, as this domain is less conserved across protein isoforms, reducing cross-reactivity. Validation typically includes confirming reactivity with recombinant ANKS1A fragments and assessing molecular weight (~120-140 kDa) in lysates from relevant tissues or cell lines.
Studies utilizing this antibody have explored ANKS1A’s interaction partners (e.g., EGFR, Notch) and its role in RTK signaling modulation, synaptic plasticity, and disease mechanisms. Its expression patterns in the brain, kidneys, and cancer tissues highlight its biological and clinical relevance. Researchers rely on this tool to dissect ANKS1A’s functional contributions to cellular physiology and pathology.
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