| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Urokinase-type plasminogen activator, U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B, Plau |
| Entrez GeneID | 18792 |
| WB Predicted band size | 48.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Plau antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-331 amino acids from the C-terminal region of mouse Plau. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是模拟的关于小鼠Plau(uPA)抗体的参考文献示例，供参考：
1. **文献名称**: "A Monoclonal Antibody Targeting Mouse uPA Inhibits Tumor Cell Invasion In Vivo"
**作者**: Zhang, L., et al.
**摘要**: 研究团队开发了一种针对小鼠uPA的单克隆抗体，证实其能特异性结合uPA并抑制酶活性。在黑色素瘤模型中，该抗体显著降低了肿瘤细胞的侵袭和转移，提示其治疗潜力。
2. **文献名称**: "Characterization of a Polyclonal Anti-Mouse Plau Antibody for Immunohistochemical Applications"
**作者**: Müller, R., et al.
**摘要**: 本文描述了一种多克隆抗体的生产与验证，该抗体通过免疫兔获得，适用于石蜡包埋组织切片中的uPA检测。实验证实其在乳腺癌模型中的高敏感性和组织特异性。
3. **文献名称**: "Neutralization of uPA Activity by a Novel Antibody Attenuates Liver Fibrosis in Mice"
**作者**: Tanaka, K., et al.
**摘要**: 研究报道了一种新型中和性抗小鼠uPA抗体，可阻断纤溶酶原激活。在肝纤维化模型中，抗体治疗显著降低了胶原沉积和炎症标志物，为纤维化治疗提供了新策略。
4. **文献名称**: "Development of a Recombinant scFv Antibody against Mouse Plau for Molecular Imaging"
**作者**: Gupta, S., et al.
**摘要**: 文章介绍了一种基于噬菌体展示技术筛选的单链抗体(scFv)，能够高亲和力结合小鼠uPA。该抗体经放射性标记后，成功用于肿瘤微环境的体内分子成像。
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**注**：以上内容为模拟生成，非真实存在的文献。实际文献检索建议通过PubMed、Google Scholar等平台使用关键词如“mouse Plau antibody”或“murine uPA antibody”进行查询。
Mouse Plau (plasminogen activator, urokinase) antibodies are tools used to study the urokinase-type plasminogen activator (uPA), a serine protease encoded by the Plau gene in mice. uPA plays a critical role in extracellular matrix remodeling, cell migration, and tissue repair by converting plasminogen to plasmin, a broad-spectrum protease. Its activity is tightly regulated through interactions with its receptor (uPAR) and inhibitors (PAI-1). Dysregulation of the uPA system is implicated in pathological processes, including cancer metastasis, inflammation, and fibrosis.
Mouse Plau-specific antibodies enable researchers to detect and quantify uPA expression in murine models, aiding mechanistic studies of its role in disease progression. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to localize uPA in tissues or measure its secretion in biological fluids. Additionally, neutralizing antibodies can block uPA activity in vivo, helping to assess its functional contributions to tumor invasion or wound healing in preclinical settings. The development of Mouse Plau antibodies has been pivotal in dissecting uPA-mediated signaling pathways and evaluating therapeutic strategies targeting this protease system in mouse-based research.
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