Rabbit Polyclonal MEFV(Center) Antibody

The MEFV gene encodes pyrin, a protein involved in regulating innate immune responses and inflammasome activity. Mutations in MEFV are linked to familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disorder characterized by recurrent fever, serositis, and elevated acute-phase reactants. Pyrin interacts with components of the inflammasome, particularly influencing interleukin-1β (IL-1β) processing. In FMF, pathogenic MEFV variants (e.g., M694V, V726A) lead to hyperactive pyrin, causing uncontrolled inflammation. Antibodies targeting pyrin (MEFV/Center antibodies) are essential tools for studying its expression, localization, and functional alterations in disease models. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess pyrin levels in cells or tissues, particularly in FMF research or diagnostics. Additionally, these antibodies help investigate pyrin's role in other inflammatory conditions, such as Behçet's disease or rheumatoid arthritis, where dysregulated inflammasome activity may contribute to pathogenesis. Recent studies also explore pyrin's interactions with microbial components, highlighting its role in pathogen sensing. Commercially available MEFV antibodies are typically validated for specificity using knockout cell lines or tissues. Their applications extend to evaluating therapeutic responses, such as IL-1 inhibitors in FMF, and understanding genotype-phenotype correlations in mutation carriers.