| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tastin, Trophinin-assisting protein, Trophinin-associated protein, TROAP |
| Entrez GeneID | 10024 |
| WB Predicted band size | 83.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TROAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human TROAP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TROAP(N-term)抗体的模拟参考文献示例(仅供参考，实际文献需通过学术数据库核实)：
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1. **文献名称**: *TROAP promotes hepatocellular carcinoma progression via Wnt/β-catenin signaling*
**作者**: Li, X., Wang, Y., et al. (2020)
**摘要**: 该研究利用针对TROAP N端区域的抗体，通过Western blot和免疫组化分析，发现TROAP在肝细胞癌中高表达，并与患者预后不良相关。抗体特异性验证表明其能有效识别内源性TROAP蛋白，支持其在Wnt通路调控中的作用。
2. **文献名称**: *Role of TROAP in spindle assembly and mitotic progression in breast cancer*
**作者**: Zhang, H., Liu, R., et al. (2019)
**摘要**: 通过使用TROAP(N-term)特异性抗体进行免疫荧光染色，研究揭示了TROAP在乳腺癌细胞有丝分裂过程中对纺锤体组装的关键作用。抗体验证实验显示其适用于细胞定位及蛋白相互作用研究。
3. **文献名称**: *TROAP as a novel biomarker for gastric cancer metastasis*
**作者**: Wang, J., Chen, T., et al. (2021)
**摘要**: 研究采用抗TROAP N端抗体进行组织微阵列分析，发现TROAP在胃癌转移组织中显著上调，并通过体外实验证实其促进肿瘤侵袭。抗体特异性通过siRNA敲降实验进一步验证。
4. **文献名称**: *Development and validation of a polyclonal antibody against human TROAP for colorectal cancer studies*
**作者**: Chen, L., Zhou, M., et al. (2018)
**摘要**: 本文报道了一种针对TROAP蛋白N端区域的多克隆抗体的开发，经ELISA、免疫印迹和免疫沉淀验证其高特异性和灵敏度。该抗体被成功应用于结直肠癌组织中TROAP表达水平的定量分析。
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**注意**：以上为基于学术文献常见结构的模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“TROAP antibody N-terminal”或“TROAP N-term epitope”检索。部分商业抗体公司(如Abcam、CST)的产品说明书也可能引用相关文献。
TROAP (Trophinin-associated protein), also known as tastin, is a cytoplasmic protein involved in cell adhesion and mitosis. It interacts with trophinin, a transmembrane adhesion molecule, to form a complex critical for embryo implantation and cell-cell interactions in various tissues. TROAP is highly expressed during the S and G2/M phases of the cell cycle, playing a role in spindle assembly and chromosomal segregation by stabilizing microtubules. Dysregulation of TROAP has been linked to cancer progression, particularly in breast, prostate, and liver cancers, where its overexpression correlates with poor prognosis and metastatic potential.
The TROAP(N-term) antibody specifically targets the N-terminal region of the TROAP protein, enabling researchers to study its expression, localization, and functional roles in cellular processes. This antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TROAP’s behavior in normal and pathological conditions. In cancer research, it helps elucidate mechanisms underlying tumor proliferation, invasion, and therapeutic resistance. Additionally, studies using this antibody have revealed TROAP’s interaction with components of the cytoskeleton and mitotic machinery, highlighting its dual role in cell adhesion and division. Its specificity for the N-terminal domain ensures minimal cross-reactivity, making it a reliable tool for both basic and translational studies aiming to explore TROAP’s contributions to development, reproduction, and oncogenesis.
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