Rabbit Polyclonal VGLL4(Center) Antibody

The VGLL4 (Center) antibody is designed to target the central region of the Vestigial-like protein 4 (VGLL4), a transcriptional co-repressor involved in regulating cell proliferation, differentiation, and apoptosis. VGLL4 functions as a key modulator of the Hippo signaling pathway, a conserved pathway critical for organ size control and tissue homeostasis. It competes with the oncogenic transcriptional co-activators YAP/TAZ for binding to TEAD transcription factors, thereby inhibiting YAP/TAZ-mediated pro-growth and anti-apoptotic gene expression. This interaction positions VGLL4 as a tumor suppressor in various cancers, including colorectal, gastric, and lung cancers. The VGLL4 (Center) antibody is commonly used in research to detect endogenous VGLL4 protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the central domain ensures recognition of full-length VGLL4 isoforms, aiding studies on VGLL4's regulatory roles in development and disease. Researchers also employ this antibody to explore therapeutic strategies targeting the Hippo-YAP pathway, as VGLL4-based peptides or mimics show potential in suppressing YAP-driven oncogenesis. Validation typically includes knockout controls or siRNA-mediated knockdown to confirm target specificity.