Rabbit Polyclonal UBAP2L Antibody

UBAP2L (Ubiquitin-Associated Protein 2-Like) is a protein implicated in diverse cellular processes, including ubiquitination, ribosome biogenesis, and RNA metabolism. It contains a conserved N-terminal UBA domain that facilitates interactions with ubiquitin and ubiquitinated proteins, linking it to protein quality control pathways. Research highlights UBAP2L's role in regulating cell proliferation, apoptosis, and stress responses, with dysregulation observed in cancers (e.g., breast, liver, colorectal) and neurological disorders. Overexpression of UBAP2L has been associated with tumor progression, potentially through modulating Wnt/β-catenin or PI3K/AKT signaling. Antibodies targeting UBAP2L are essential tools for investigating its expression patterns, molecular interactions, and pathological roles. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study UBAP2L localization in tissues or cultured cells. Recent studies also explore its diagnostic or therapeutic potential, such as correlating UBAP2L levels with cancer prognosis. However, challenges remain in understanding isoform-specific functions and post-translational modifications, underscoring the need for high-specificity antibodies. Commercial UBAP2L antibodies are typically developed in hosts like rabbits or mice, validated for cross-reactivity and application compatibility, aiding both basic research and translational studies.