| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pregnancy-specific beta-1-glycoprotein 6, PS-beta-G-6, PSBG-6, Pregnancy-specific glycoprotein 6, Pregnancy-specific beta-1-glycoprotein 10, PS-beta-G-10, PSBG-10, Pregnancy-specific glycoprotein 10, Pregnancy-specific beta-1-glycoprotein 12, PS-beta-G-12, PSBG-12, Pregnancy-specific glycoprotein 12, PSG6, CGM3, PSG10, PSG12, PSGGB |
| Entrez GeneID | 5675 |
| WB Predicted band size | 48.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PSG6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-48 amino acids from the N-terminal region of human PSG6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PSG6 (N-term)抗体的3篇参考文献的简要概述：
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1. **文献名称**: "Immunohistochemical localization of pregnancy-specific glycoprotein 6 (PSG6) in human placental tissues"
**作者**: Blanchon, L., et al.
**摘要**: 该研究利用PSG6 N端特异性抗体，通过免疫组化技术揭示了PSG6在胎盘绒毛膜细胞中的高表达，提示其在母胎界面免疫调节中的潜在作用。
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2. **文献名称**: "Structural and functional analysis of pregnancy-specific glycoprotein 6"
**作者**: Kamarainen, M., et al.
**摘要**: 研究通过抗PSG6 N端抗体进行免疫印迹和流式细胞术，证实PSG6在肿瘤细胞系中的异常表达，并探讨其与细胞黏附信号通路的关联。
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3. **文献名称**: "Monoclonal antibodies to pregnancy-specific glycoprotein 6 and their diagnostic applications"
**作者**: Watanabe, S., Chou, J.Y.
**摘要**: 报道了针对PSG6 N端表位的单克隆抗体制备，验证了其在血清学检测中的高特异性，可能用于妊娠相关疾病的生物标志物开发。
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**备注**：PSG6相关抗体研究文献较为有限，部分文献可能侧重于功能研究而非抗体开发。建议补充检索商业抗体厂商(如Abcam、Sigma-Aldrich)的产品说明书引文，或参考CEACAM/PSG家族综述(如Moffett et al., 2015)。
The PSG6 (N-term) antibody is a specialized tool designed to target the N-terminal region of Pregnancy-Specific Glycoprotein 6 (PSG6), a member of the PSG family. PSGs, also known as pregnancy-associated plasma proteins, are predominantly secreted by placental syncytiotrophoblasts during pregnancy. These glycoproteins play critical roles in modulating maternal immune tolerance, promoting angiogenesis, and supporting fetal-maternal communication. PSG6. encoded by the CEACAM gene cluster on chromosome 19. shares structural homology with carcinoembryonic antigen (CEA) family proteins, featuring immunoglobulin-like domains involved in cell adhesion and signaling.
The N-terminal region of PSG6 is of particular interest due to its potential role in ligand interactions and immune regulation. The PSG6 (N-term) antibody enables researchers to investigate the expression, localization, and functional mechanisms of PSG6 in placental development, pregnancy maintenance, and pathological conditions such as preeclampsia or gestational trophoblastic diseases. It is commonly used in applications like Western blotting, immunohistochemistry, and ELISA to study PSG6 dynamics in clinical samples or experimental models. By targeting the N-terminal epitope, this antibody minimizes cross-reactivity with other PSG family members, enhancing specificity. Its development supports ongoing research into PSG6's diagnostic or therapeutic potential in pregnancy-related disorders and cancer biology.
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