| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C, PPIase A-like 4A, Chromosome 1-amplified sequence 2, COAS-2, Cyclophilin homolog overexpressed in liver cancer, PPIAL4A, COAS2 |
| Entrez GeneID | 653505 |
| WB Predicted band size | 18.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPIAL4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-92 amino acids from the Central region of human PPIAL4A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPIAL4A抗体的假设性参考文献示例(请注意，PPIAL4A相关研究较为有限，以下内容仅供参考，实际文献需通过学术数据库核实)：
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1. **文献名称**: *"Characterization of a Novel PPIAL4A-Specific Antibody and Its Role in Apoptosis Regulation"*
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种针对PPIAL4A蛋白的多克隆抗体，验证了其特异性及在HeLa细胞中的表达定位。实验表明，PPIAL4A通过调控Bcl-2家族蛋白影响线粒体依赖性凋亡通路。
2. **文献名称**: *"PPIAL4A as a Biomarker in Breast Cancer: Immunohistochemical Analysis Using a Novel Monoclonal Antibody"*
**作者**: Smith J, et al.
**摘要**: 报道了一种高亲和力抗PPIAL4A单克隆抗体的开发，并用于乳腺癌组织芯片分析。结果显示，PPIAL4A高表达与患者预后不良显著相关，提示其作为潜在治疗靶点。
3. **文献名称**: *"Structural Insights into PPIAL4A-Calcineurin Interaction Revealed by Co-Immunoprecipitation Studies"*
**作者**: Lee H, et al.
**摘要**: 利用PPIAL4A抗体进行免疫共沉淀实验，发现其与钙调磷酸酶(calcineurin)存在直接互作，可能参与T细胞活化信号通路的调控，为自身免疫疾病研究提供新方向。
4. **文献名称**: *"Validation of PPIAL4A Antibody Specificity for Flow Cytometry Applications"*
**作者**: BioTech Antibody Solutions (公司技术报告)
**摘要**: 评估了商用PPIAL4A抗体在流式细胞术中的性能，确认其在人外周血单核细胞中的表面标记检测有效性，并提供了优化实验条件建议。
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**注意**：以上文献为示例性质，若实际研究中未检索到PPIAL4A相关结果，可能是名称拼写差异或研究较少所致。建议：
1. 核对基因/蛋白名称(如PPIA、PPIAL4G等同家族成员);
2. 扩大检索关键词(如“Cyclophilin-like antibody”);
3. 查阅抗体公司产品说明书引用文献(如Thermo Fisher、Abcam等)。
The PPIAL4A (peptidylprolyl isomerase A like 4A) antibody is designed to detect PPIAL4A, a protein belonging to the cyclophilin family, which is characterized by its peptidyl-prolyl cis-trans isomerase (PPIase) activity. Cyclophilins play critical roles in protein folding, cellular signaling, and immune regulation through interactions with cyclosporine and other ligands. PPIAL4A, a less studied member, shares structural homology with cyclophilin A (CypA) but exhibits distinct expression patterns and potential functional divergences. It is implicated in modulating protein-protein interactions, intracellular trafficking, and apoptosis.
The PPIAL4A antibody is primarily utilized in research to investigate the protein’s expression, localization, and molecular interactions in various tissues and cell types. It is commonly applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies suggest PPIAL4A may have roles in cancer progression, neurological disorders, and immune responses, though its precise biological mechanisms remain under exploration. This antibody is crucial for elucidating PPIAL4A’s contribution to cellular pathways and disease pathogenesis. Host species (e.g., rabbit, mouse) and reactivity (human, mouse, rat) vary by product; validation includes specificity checks via knockout controls. Researchers rely on this tool to uncover PPIAL4A’s functional relevance in health and disease.
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