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Rabbit Polyclonal PAFAH1B2 Antibody

  • 中文名： PAFAH1B2抗体
  • 别    名： Platelet-activating factor acetylhydrolase IB subunit beta, PAF acetylhydrolase 30 kDa subunit, PAF-AH 30 kDa subunit, PAF-AH subunit beta, PAFAH subunit beta, PAFAH1B2, PAFAHB
货号: IPDX34001
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPlatelet-activating factor acetylhydrolase IB subunit beta, PAF acetylhydrolase 30 kDa subunit, PAF-AH 30 kDa subunit, PAF-AH subunit beta, PAFAH subunit beta, PAFAH1B2, PAFAHB
Entrez GeneID5049
WB Predicted band size25.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PAFAH1B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-89 amino acids from the Central region of human PAFAH1B2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于PAFAH1B2抗体的参考文献概览(虚构示例，供格式参考)：

1. **文献名称**：*PAFAH1B2 overexpression promotes tumorigenesis in non-small cell lung cancer*

**作者**：Zhang Y et al.

**摘要**：本研究通过Western blot和免疫组化分析，证实PAFAH1B2在肺癌组织中高表达，并发现其通过调控PI3K/AKT通路促进肿瘤细胞增殖，实验中使用特异性PAFAH1B2抗体验证蛋白表达水平。

2. **文献名称**：*LIS1/PAFAH1B2 complex regulates neuronal migration via microtubule dynamics*

**作者**：Hirotsune S et al.

**摘要**：作者利用PAFAH1B2多克隆抗体进行免疫共沉淀和免疫荧光染色，揭示了PAFAH1B2与LIS1蛋白互作调控神经元迁移的分子机制，发现其缺陷导致皮质发育异常。

3. **文献名称**：*Prognostic value of PAFAH1B2 in colorectal cancer: a tissue microarray study*

**作者**：Wang L et al.

**摘要**：通过组织芯片结合PAFAH1B2单克隆抗体的免疫组化分析，发现PAFAH1B2高表达与结直肠癌患者生存率负相关，提示其作为潜在预后标志物的价值。

(注：以上文献为示例，实际文献需通过PubMed或Google Scholar检索关键词如"PAFAH1B2 antibody"、"PAFAH1B2 Western blot"等获取。)

背景信息

The PAFAH1B2 antibody targets the protein Platelet-Activating Factor Acetylhydrolase 1B2 (PAFAH1B2), a subunit of the intracellular heterotrimeric PAFAH enzyme complex. This complex, composed of PAFAH1B1. PAFAH1B2. and PAFAH1B3. hydrolyzes platelet-activating factor (PAF) and related phospholipids, regulating inflammatory responses and cell signaling. PAFAH1B2. also known as LIS2 or alpha2 subunit, stabilizes the catalytic activity of the complex. While PAFAH1B1 is extensively studied for its role in neuronal migration (e.g., Miller-Dieker lissencephaly), PAFAH1B2 has gained attention for its overexpression in cancers, including breast, lung, and hepatocellular carcinoma, where it may promote tumor progression via lipid metabolism and survival pathways. Antibodies against PAFAH1B2 are essential tools for detecting its expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has linked PAFAH1B2 to chemoresistance and metastasis, suggesting its potential as a therapeutic target or biomarker. However, its precise mechanisms in oncogenesis remain under investigation, necessitating further functional studies to elucidate its roles in both physiological and pathological contexts.

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