Rabbit Polyclonal CCIN Antibody

CCIN antibody targets Calicin (CCIN), a protein predominantly expressed in the testis, particularly in spermatids and mature sperm. Calicin plays a critical role in spermiogenesis by stabilizing the nuclear architecture during sperm head elongation and condensation. It localizes to the calyx of the sperm head, a transient structure involved in nuclear shaping, and interacts with cytoskeletal components like actin and tubulin. Research on CCIN antibodies has been instrumental in studying male infertility, as calicin dysfunction is linked to teratozoospermia (abnormal sperm morphology) and failed fertilization. These antibodies are widely used in immunohistochemistry, immunofluorescence, and Western blotting to analyze calicin expression patterns, cellular distribution, and molecular interactions in germ cells. Beyond reproductive biology, CCIN antibodies have also aided investigations into cell polarity and nuclear-cytoskeletal crosstalk in somatic cells. Recent studies explore calicin's potential role in cancer, given its occasional overexpression in tumors. However, its precise mechanisms in oncogenesis remain unclear. As a research tool, CCIN antibodies continue to advance understanding of gametogenesis, cytoskeletal dynamics, and related pathologies. Commercial availability since the early 2000s has standardized their use across fertility clinics and cell biology labs.