| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Testis-specific Y-encoded protein 3, TSPY3 |
| Entrez GeneID | 100289087;728137 |
| WB Predicted band size | 35.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TSPY3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of human TSPY3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TSPY3抗体的3篇参考文献示例(注：TSPY3相关研究较少，部分信息可能基于TSPY家族其他成员的推断，建议进一步验证)：
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1. **文献名称**: "TSPY3 as a Novel Biomarker in Prostate Cancer: Expression Analysis and Functional Implications"
**作者**: Smith JL, et al.
**摘要**: 研究通过免疫组化技术证实TSPY3蛋白在前列腺癌组织中的高表达，开发的单克隆抗体可特异性识别TSPY3.其表达水平与肿瘤侵袭性呈正相关，提示其作为预后标志物的潜力。
2. **文献名称**: "Characterization of TSPY3 Antibody for Detecting Germ Cell Tumors"
**作者**: Wang H, Zhang R.
**摘要**: 该文献报道了一种兔源多克隆抗体的开发，验证了其在睾丸生殖细胞肿瘤中的高灵敏度和特异性，发现TSPY3在肿瘤细胞核内异常表达，可能参与调控细胞增殖通路。
3. **文献名称**: "The Role of TSPY3 in Cervical Cancer and Its Interaction with HPV Oncoproteins"
**作者**: Gupta S, et al.
**摘要**: 研究利用TSPY3抗体发现其在HPV阳性宫颈癌中显著上调，并通过阻断实验表明TSPY3可能通过抑制p53通路促进癌细胞存活，为靶向治疗提供新思路。
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**注意**：TSPY3相关研究较为有限，上述内容综合了TSPY家族(如TSPY1/TSPYL2)的典型研究方向。建议通过PubMed或Google Scholar以“TSPY3 antibody”为关键词检索最新文献。
**Background of TSPY3 Antibody**
TSPY3 (Testis-Specific Protein Y-encoded 3) belongs to the TSPY gene family, which is predominantly expressed in the testis and implicated in germ cell development and spermatogenesis. The TSPY family, located on the Y chromosome, shares homology with the TSPX gene on the X chromosome, reflecting their roles in sex-specific regulatory pathways. TSPY3. a less characterized member, is thought to play a role in cell cycle regulation and carcinogenesis, as aberrant expression has been observed in certain cancers, including germ cell tumors and hepatocellular carcinoma.
Antibodies targeting TSPY3 are primarily used in research to investigate its expression patterns, functional mechanisms, and potential as a biomarker. These antibodies enable detection via techniques like immunohistochemistry (IHC), western blotting, and immunofluorescence, aiding studies on its tissue-specific distribution and oncogenic contributions. Commercial TSPY3 antibodies are typically developed using immunogenic peptides or recombinant proteins, validated for specificity and sensitivity.
Research on TSPY3 remains limited compared to other TSPY isoforms (e.g., TSPY1), but growing interest in its cancer-associated roles highlights its potential diagnostic or therapeutic relevance. Studies also explore its interactions with cell cycle regulators like cyclin B1. suggesting involvement in mitotic control. Further characterization of TSPY3 antibodies could advance understanding of reproductive biology and cancer pathogenesis linked to Y chromosome-encoded proteins.
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