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Rabbit Polyclonal TAS2R31 Antibody

  • 中文名： TAS2R31抗体
  • 别    名： Taste receptor type 2 member 31, T2R31, Taste receptor type 2 member 44, T2R44, Taste receptor type 2 member 53, T2R53, TAS2R31, TAS2R44
货号: IPDX33993
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMCM2, CDC47, P85MCM, P1CDC47, PNAS146, P1.1-MCM3
WB Predicted band size81 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human MCM7
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于TAS2R31抗体的3篇参考文献，包含文献名称、作者及摘要概括：

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1. **"Characterization of TAS2R31 Antibodies for Bitter Taste Receptor Localization in Human Airway Epithelium"**

*Authors: Smith J, Doe A, Lee C*

摘要：本研究开发并验证了一种特异性识别TAS2R31受体的多克隆抗体，通过免疫组化证实其在人气道上皮细胞中的表达，并探讨其与呼吸道炎症反应的潜在关联。

2. **"Bitter Taste Receptors in the Gut: TAS2R31 Antibody-Based Detection and Functional Analysis"**

*Authors: Zhang Y, Wang L, Kim M*

摘要：利用抗TAS2R31抗体分析胃肠道中苦味受体的分布，发现其在肠内分泌细胞中高表达，可能参与调节胃肠激素分泌及肠道屏障功能。

3. **"A Monoclonal Antibody Against TAS2R31 Reveals Its Role in Type 2 Diabetes Pathogenesis"**

*Authors: Brown K, Patel R, Gonzalez S*

摘要：通过单克隆抗体阻断TAS2R31活性，发现其与胰岛素抵抗相关，提示该受体可能成为代谢性疾病的新型治疗靶点。

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注：上述文献为示例，实际引用需根据具体研究补充真实来源。若需精准文献，建议通过PubMed或Web of Science以关键词“TAS2R31 antibody”进一步检索。

背景信息

TAS2R31. a member of the bitter taste receptor (TAS2R) family, is a G protein-coupled receptor (GPCR) primarily expressed in taste buds but also found in non-gustatory tissues like the respiratory, gastrointestinal, and reproductive systems. It detects bitter compounds, triggering cellular responses that influence taste perception, metabolism, and innate immune functions. TAS2R31 antibodies are tools developed to study the receptor’s expression, localization, and physiological roles. Due to TAS2R31’s structural complexity (short extracellular domains, transmembrane topology), generating specific antibodies is challenging. Most antibodies target intracellular epitopes (e.g., C-terminal regions) for applications like Western blotting, immunohistochemistry, or flow cytometry. Polyclonal and monoclonal variants exist, with validation often relying on knockout models or peptide-blocking assays. Research using TAS2R31 antibodies has explored its involvement in bronchodilation, antimicrobial secretion, and metabolic regulation, linking it to conditions like asthma, obesity, and infections. However, cross-reactivity with other TAS2Rs remains a concern, necessitating careful experimental controls. These antibodies are critical for elucidating TAS2R31’s dual role in chemosensation and extragustatory pathophysiology, with potential applications in drug discovery targeting bitter receptor pathways.

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