Rabbit Polyclonal TAS2R31 Antibody

TAS2R31. a member of the bitter taste receptor (TAS2R) family, is a G protein-coupled receptor (GPCR) primarily expressed in taste buds but also found in non-gustatory tissues like the respiratory, gastrointestinal, and reproductive systems. It detects bitter compounds, triggering cellular responses that influence taste perception, metabolism, and innate immune functions. TAS2R31 antibodies are tools developed to study the receptor’s expression, localization, and physiological roles. Due to TAS2R31’s structural complexity (short extracellular domains, transmembrane topology), generating specific antibodies is challenging. Most antibodies target intracellular epitopes (e.g., C-terminal regions) for applications like Western blotting, immunohistochemistry, or flow cytometry. Polyclonal and monoclonal variants exist, with validation often relying on knockout models or peptide-blocking assays. Research using TAS2R31 antibodies has explored its involvement in bronchodilation, antimicrobial secretion, and metabolic regulation, linking it to conditions like asthma, obesity, and infections. However, cross-reactivity with other TAS2Rs remains a concern, necessitating careful experimental controls. These antibodies are critical for elucidating TAS2R31’s dual role in chemosensation and extragustatory pathophysiology, with potential applications in drug discovery targeting bitter receptor pathways.