| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein MOX-1, Mesenchyme homeobox 1, MEOX1, MOX1 |
| Entrez GeneID | 4222 |
| WB Predicted band size | 28.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MEOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the Central region of human MEOX1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MEOX1抗体的3篇参考文献示例(文献信息为模拟内容，实际文献需通过数据库检索获取)：
1. **文献名称**：MEOX1 regulates skeletal muscle differentiation through transcriptional activation of myogenic factors
**作者**：Smith A, et al.
**摘要**：该研究利用MEOX1特异性抗体通过免疫共沉淀和ChIP实验，证明MEOX1蛋白直接结合肌肉分化相关基因(如MyoD)的启动子区域，调控成肌细胞分化过程。
2. **文献名称**：Aberrant expression of MEOX1 in glioblastoma correlates with tumor progression
**作者**：Chen L, et al.
**摘要**：通过免疫组化(使用MEOX1多克隆抗体)和Western blot分析，发现MEOX1在胶质母细胞瘤中高表达，且其表达水平与患者预后不良相关，提示其可作为潜在治疗靶点。
3. **文献名称**：MEOX1 deficiency disrupts vascular development in mouse embryos
**作者**：Wang Y, et al.
**摘要**：研究通过免疫荧光染色(使用MEOX1单克隆抗体)结合基因敲除模型，揭示MEOX1在小鼠胚胎血管形成中通过调控VEGF信号通路发挥关键作用。
注：以上文献信息为示例，实际应用中建议通过PubMed、Google Scholar等平台检索关键词“MEOX1 antibody”或“MEOX1 immunohistochemistry”获取具体文献，并优先选择近五年内发表于《Development》《Cancer Research》等期刊的研究。
The MEOX1 antibody is a tool used to detect the Mesenchyme Homeobox 1 (MEOX1) protein, a transcription factor encoded by the *MEOX1* gene. MEOX1 belongs to the homeobox gene family, which plays critical roles in embryonic development, particularly in mesodermal tissue formation, skeletal myogenesis, and vascular patterning. It regulates gene expression by binding to specific DNA sequences, influencing cellular differentiation, proliferation, and apoptosis. Dysregulation of MEOX1 has been implicated in developmental disorders and diseases such as cancer, where it may act as a tumor suppressor or promoter depending on the context.
MEOX1 antibodies are widely utilized in research to study its expression, localization, and function in tissues and cell lines. They are essential in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercially available MEOX1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the protein. Validation data, including knockout controls and cross-reactivity assessments, are crucial for ensuring antibody specificity.
Research involving MEOX1 antibodies has advanced understanding of its role in developmental biology, angiogenesis, and cancer progression. For example, studies link reduced MEOX1 expression to poor prognosis in gliomas and colorectal cancer. These antibodies also aid in exploring potential therapeutic targets by elucidating MEOX1's interaction with signaling pathways like Wnt or TGF-β.
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