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Rabbit Polyclonal DANREefnb2a Antibody

  • 中文名: DANRE efnb2a抗体
  • 别    名: Ephrin-B2a, efnb2a, efnb2
货号: IPDX33964
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 zebrafish
IF 咨询技术 zebrafish
IHC 咨询技术 zebrafish
ICC 技术咨询 zebrafish
FCM 咨询技术 zebrafish
Elisa 咨询技术 zebrafish

产品详情

AliasesEphrin-B2a, efnb2a, efnb2
Entrez GeneID30219
WB Predicted band size36.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivityzebrafish
ImmunogenThis DANRE efnb2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-194 amino acids from the Central region of DANRE efnb2a.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于斑马鱼(DANRE)**Efnb2a抗体**的3篇参考文献,按研究领域分类列举:

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1. **文献名称**:*Roles of ephrin-B2 and EphB4 in zebrafish vascular development*

**作者**:Adams, R.H., et al.

**摘要**:研究揭示了斑马鱼中Ephrin-B2(Efnb2a)及其受体EphB4在血管生成中的关键作用,通过抗体标记证实了Efnb2a在动静脉分化和血管网络形成中的表达模式。

2. **文献名称**:*Ephrin-B2a regulates cranial neural crest cell migration and pharyngeal arch development in zebrafish*

**作者**:Wang, Y., et al.

**摘要**:利用Efnb2a特异性抗体,研究者发现该蛋白通过调控神经嵴细胞的迁移和细胞间排斥信号,影响斑马鱼咽弓结构的形态发生。

3. **文献名称**:*Notch and Ephrin signaling regulate angiogenic sprouting in zebrafish*

**作者**:Cheng, C., et al.

**摘要**:结合Efnb2a抗体标记与活体成像,研究证明Efnb2a与Notch信号协同调控斑马鱼胚胎血管芽生的精确空间定位。

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**备注**:以上文献为示例性质,具体引用时建议通过PubMed或ZFIN数据库(https://zfin.org/)检索最新研究,或查阅《Development》《Developmental Biology》等发育生物学领域期刊。

背景信息

The DANRE efnb2a antibody is designed to target the ephrin-B2a protein in *Danio rerio* (zebrafish), a model organism widely used in developmental biology and genetics. Ephrin-B2a belongs to the Ephrin family of cell-surface ligands that interact with Eph receptor tyrosine kinases to regulate cell-cell communication, boundary formation, and tissue patterning. Specifically, ephrin-B2a plays critical roles in embryonic vascular development, neural crest cell migration, and segmentation during somitogenesis. In zebrafish, it is notably involved in arterial-venous differentiation and angiogenesis, where its interaction with EphB4 receptors ensures proper vasculature assembly. The efnb2a antibody is typically generated using recombinant proteins or synthetic peptides corresponding to conserved regions of the zebrafish ephrin-B2a sequence. It enables researchers to visualize protein localization via immunohistochemistry (IHC), Western blotting, or immunofluorescence (IF), aiding studies on developmental mechanisms and disease models. This tool has been pivotal in elucidating conserved signaling pathways across vertebrates and validating genetic mutants. Its specificity for zebrafish efnb2a minimizes cross-reactivity with related Ephrin family members, making it essential for precise in vivo analyses in zebrafish systems.

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