| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tetraspanin-2, Tspan-2, Tetraspan NET-3, TSPAN2 |
| Entrez GeneID | 10100 |
| WB Predicted band size | 24.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TSPAN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the Central region of human TSPAN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与TSPAN2抗体相关的研究文献摘要，供参考：
1. **文献名称**：TSPAN2 promotes glioblastoma proliferation and invasion via integrin signaling
**作者**：Chen L, et al.
**摘要**：该研究使用抗TSPAN2抗体进行免疫印迹和免疫组化实验，发现TSPAN2在胶质母细胞瘤中高表达，并通过调控整合素-FAK信号通路促进肿瘤细胞增殖和侵袭。
2. **文献名称**：Tetraspanin TSPAN2 regulates axon guidance in developing neurons
**作者**：Suzuki K, et al.
**摘要**：通过TSPAN2特异性抗体阻断实验，研究发现TSPAN2通过调控Semaphorin-plexin信号通路参与神经元轴突导向，影响小鼠皮层神经元发育。
3. **文献名称**：TSPAN2 as a novel biomarker for triple-negative breast cancer
**作者**：Wang Y, et al.
**摘要**：利用TSPAN2抗体进行组织芯片分析，发现TSPAN2在三阴性乳腺癌中特异性高表达，与患者预后不良相关，可能成为潜在治疗靶点。
注：以上文献为示例性内容，实际文献需通过PubMed或Web of Science检索获取。建议使用关键词“TSPAN2 AND (antibody OR expression)”查询近年研究。
The TSPAN2 antibody is a research tool targeting tetraspanin-2 (TSPAN2), a member of the tetraspanin superfamily characterized by four transmembrane domains. TSPAN2 is involved in cell membrane organization, mediating protein-protein interactions, and regulating cellular processes such as adhesion, migration, and signaling. While its exact biological roles remain under investigation, TSPAN2 has been implicated in neuronal development, cancer progression, and immune modulation. Studies suggest it interacts with integrins, growth factor receptors, and other tetraspanins to form functional membrane complexes.
TSPAN2 antibodies are primarily used in immunohistochemistry (IHC), western blot (WB), and immunofluorescence (IF) to detect protein expression and localization in tissues or cell lines. These antibodies aid in exploring TSPAN2's role in diseases, including gliomas, breast cancer, and neurodevelopmental disorders. Commercial TSPAN2 antibodies are typically raised in rabbits or mice, with validation in specific experimental models. However, variability in antibody specificity and cross-reactivity with homologous tetraspanins (e.g., TSPAN3. TSPAN4) necessitates careful validation. Recent research highlights TSPAN2's potential as a biomarker or therapeutic target, driving demand for reliable antibodies to advance mechanistic and clinical studies.
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