| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DNA-directed RNA polymerase I subunit RPA12, Zinc ribbon domain-containing protein 1, ZNRD1, RPA12 |
| Entrez GeneID | 30834 |
| WB Predicted band size | 13.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ZNRD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 88-127 amino acids from human ZNRD1. |
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以下是关于ZNRD1抗体的3篇示例参考文献(内容为模拟示例，建议通过学术数据库获取真实文献)：
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1. **文献名称**: *ZNRD1 Antibody Detects Differential Expression in Gastric Cancer Tissues*
**作者**: Li X, et al.
**摘要**: 该研究通过ZNRD1抗体进行免疫组化分析，发现ZNRD1在胃癌组织中的表达显著低于正常组织，提示其可能作为肿瘤抑制因子参与胃癌进展，并可能成为预后标志物。
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2. **文献名称**: *Autoantibodies Against ZNRD1 in Systemic Lupus Erythematosus*
**作者**: Wang Y, et al.
**摘要**: 研究利用ZNRD1抗体检测系统性红斑狼疮(SLE)患者血清，发现患者体内存在针对ZNRD1的自身抗体，提示ZNRD1可能与SLE的免疫病理机制相关。
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3. **文献名称**: *ZNRD1 Regulates HIV-1 Replication via Interaction with Viral Proteins*
**作者**: Smith J, et al.
**摘要**: 通过ZNRD1抗体的免疫共沉淀实验，揭示了ZNRD1与HIV-1整合酶的直接相互作用，表明其在病毒复制中的调控作用，为抗病毒治疗提供了新靶点。
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**注意**：以上文献信息为示例，实际文献需通过PubMed、Google Scholar等平台检索(关键词：ZNRD1 antibody, ZNRD1 immune response)。
The zinc ribbon domain-containing protein 1 (ZNRD1) is a nuclear protein implicated in transcriptional regulation and DNA repair. Structurally, it contains a conserved zinc ribbon motif, a domain often associated with nucleic acid binding or protein-protein interactions. ZNRD1 interacts with RNA polymerase II and other transcription-related factors, suggesting a role in modulating RNA synthesis or chromatin remodeling. It has also been linked to cellular stress responses and apoptosis regulation.
Interest in ZNRD1 antibodies stems from its association with disease pathways. Studies highlight its overexpression in certain cancers, including gastric and colorectal cancers, where it may promote tumor progression by enhancing cell proliferation or evading apoptosis. Conversely, ZNRD1 has been identified as a host dependency factor for viral pathogens like HIV-1. influencing viral replication through interactions with host transcriptional machinery.
ZNRD1 antibodies are primarily used as research tools to investigate its expression patterns, subcellular localization, and molecular interactions. These antibodies (often polyclonal or monoclonal, derived from rabbit or mouse) enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent work explores ZNRD1's potential as a biomarker for cancer prognosis or a therapeutic target, though its dual roles in promoting both oncogenesis and antiviral responses require further mechanistic clarification. Ongoing research aims to unravel its context-dependent functions in health and disease.
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