| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear pore complex protein Nup93, 93 kDa nucleoporin, Nucleoporin Nup93, NUP93, KIAA0095 |
| Entrez GeneID | 9688 |
| WB Predicted band size | 93.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This NUP93 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 20-54 amino acids from the human NUP93. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于NUP93 (N-Term)抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*NUP93 regulates the assembly and trafficking of the nuclear pore complex in vertebrates*
**作者**：Braun DA, et al.
**摘要**：该研究利用NUP93 (N-Term)抗体，通过免疫荧光和免疫沉淀技术，揭示了NUP93在脊椎动物核孔复合体(NPC)组装中的关键作用。研究发现，NUP93的N端结构域与其他核孔蛋白相互作用，维持核膜的通透性屏障功能。
2. **文献名称**：*Mutations in NUP93 cause steroid-resistant nephrotic syndrome by disrupting nuclear pore complex function*
**作者**：Hwang DY, et al.
**摘要**：本研究通过Western blot和免疫组化实验(使用NUP93 N-Term抗体)，发现NUP93基因突变导致核孔复合体功能异常，进而引发激素抵抗型肾病综合征。抗体检测显示患者肾细胞中NUP93表达显著降低。
3. **文献名称**：*Proteomic analysis of nuclear pore complex assembly intermediates using NUP93-specific antibodies*
**作者**：Vargas JD, et al.
**摘要**：该文献报道了一种基于NUP93 (N-Term)抗体的蛋白质组学方法，用于分离核孔复合体组装中间体。研究发现NUP93的N端区域在早期组装阶段与其他核心核孔蛋白(如NUP155和NUP205)存在动态相互作用。
(注：上述文献信息为示例性内容，实际引用时需核对真实文献。)
The NUP93 (N-Term) antibody specifically targets the N-terminal region of nucleoporin 93 (NUP93), a key component of the nuclear pore complex (NPC). NPCs are large protein assemblies embedded in the nuclear envelope, mediating selective transport of macromolecules between the nucleus and cytoplasm. NUP93 plays a structural and functional role in NPC assembly and stability, forming part of the inner pore scaffold. It interacts with other nucleoporins, such as NUP155 and NUP205. to maintain NPC architecture and regulate nucleocytoplasmic transport.
Mutations in NUP93 are linked to human diseases, including steroid-resistant nephrotic syndrome and developmental disorders, highlighting its biological importance. The N-terminal region of NUP93 is critical for its localization and interactions within the NPC. Antibodies targeting this region are widely used in research to study NPC dynamics, subcellular localization, and expression levels via techniques like Western blotting, immunofluorescence, and immunohistochemistry.
Studies employing NUP93 (N-Term) antibodies have advanced understanding of NPC dysfunction in cancer, viral infections, and genetic disorders. For example, altered NUP93 expression has been observed in certain cancers, suggesting potential roles in tumorigenesis. Validated for specificity and sensitivity, this antibody serves as a vital tool for exploring NPC-related mechanisms in cellular physiology and disease pathology. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) may vary depending on the product source.
×
