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Rabbit Polyclonal VNN1(N-Term) Antibody

  • 中文名: VNN1 (N-Term)抗体
  • 别    名: Pantetheinase, 3.5.1.92, Pantetheine hydrolase, Tiff66, Vascular non-inflammatory molecule 1, Vanin-1, VNN1
货号: IPDX33934
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPantetheinase, 3.5.1.92, Pantetheine hydrolase, Tiff66, Vascular non-inflammatory molecule 1, Vanin-1, VNN1
Entrez GeneID8876
WB Predicted band size57.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis VNN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-175 amino acids from human VNN1.

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参考文献

以下是关于VNN1 (N-Term)抗体的3篇参考文献示例(注:部分内容为虚构示例,仅用于演示格式):

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1. **文献名称**: *Vanin-1 Regulates Intestinal Barrier Function via Epithelial Cell Migration*

**作者**: Martin, P. et al.

**摘要**: 本研究利用VNN1 (N-Term)特异性抗体,通过免疫组化和Western blot分析,揭示了Vanin-1蛋白在小鼠肠道上皮细胞中的表达模式。研究发现,VNN1通过调节细胞迁移相关通路,影响肠道屏障完整性,可能为炎症性肠病提供治疗靶点。

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2. **文献名称**: *VNN1 as a Biomarker for Oxidative Stress in Type 2 Diabetes*

**作者**: Chen, L. et al.

**摘要**: 作者使用针对VNN1 N端的单克隆抗体,检测了糖尿病患者血清及组织样本中Vanin-1的表达水平。结果表明,VNN1与氧化应激标志物显著相关,提示其可作为糖尿病并发症的潜在生物标志物。

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3. **文献名称**: *Targeting VNN1 in Cancer Metastasis: A Functional Study Using Antibody Blockade*

**作者**: Sato, K. et al.

**摘要**: 该研究通过VNN1 (N-Term)抗体阻断实验,证实Vanin-1在肿瘤细胞侵袭中的作用。体内外实验显示,抑制VNN1的N端结构域可减少金属蛋白酶活性,从而抑制肺癌转移。

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**备注**:以上文献为示例性质,实际引用需通过学术数据库(如PubMed、Web of Science)检索具体论文。建议使用关键词“VNN1 antibody N-terminal”或“Vanin-1 epitope mapping”进一步查找最新研究。

背景信息

The VNN1 (N-Term) antibody is a specific immunological tool designed to target the N-terminal region of the Vanin-1 (VNN1) protein, a member of the vanin family of pantetheinases. VNN1 is a GPI-anchored ectoenzyme that catalyzes the hydrolysis of pantetheine to produce cysteamine and pantothenic acid (vitamin B5), playing roles in oxidative stress response, inflammation, and cellular metabolism. It is highly expressed in tissues like the liver, kidney, and intestines, and is implicated in immune regulation, tissue repair, and lipid metabolism. The N-terminal domain of VNN1 is critical for its enzymatic activity and interactions with other proteins, such as glutathione peroxidase (GPX), which links it to redox homeostasis.

The VNN1 (N-Term) antibody is commonly used in research to study the protein's expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region allows researchers to distinguish VNN1 from other vanin family members (e.g., VNN2. VNN3) and investigate its unique biological roles. Studies utilizing this antibody have contributed to understanding VNN1's involvement in inflammatory diseases, cancer progression, and metabolic disorders. Validation of the antibody typically includes testing on knockout models or siRNA-treated cells to confirm target specificity. Overall, it serves as a key reagent for exploring VNN1's pathophysiological mechanisms and therapeutic potential.

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