| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leukemia inhibitory factor receptor, LIF receptor, LIF-R, CD118, LIFR |
| Entrez GeneID | 3977 |
| WB Predicted band size | 123.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This LIFR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1021-1055 amino acids from the C-terminal region of human LIFR. |
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以下是关于LIFR抗体的3篇文献示例(注：文献为虚构示例，实际文献需通过数据库检索确认)：
1. **"LIFR Antibody Validation in Breast Cancer Metastasis Studies"**
*作者：Yu H, et al.*
摘要：该研究利用特异性LIFR抗体验证了LIFR在乳腺癌细胞中的表达，发现LIFR通过激活STAT3信号通路促进肿瘤转移，抗体在Western blot和免疫组化中表现出高特异性。
2. **"Targeting LIFR in Multiple Myeloma: Therapeutic Implications"**
*作者：Weis-Garcia F, et al.*
摘要：通过LIFR抗体阻断实验，研究发现LIFR在多发性骨髓瘤中调控肿瘤细胞存活和耐药性，抗体介导的LIFR抑制显著增强化疗敏感性，提示其作为潜在治疗靶点。
3. **"LIFR Antibody Application in Glioblastoma Stem Cell Isolation"**
*作者：Smith J, et al.*
摘要：研究利用LIFR抗体分选胶质母细胞瘤干细胞，证实LIFR阳性细胞具有更强的自我更新能力，抗体流式分选为靶向肿瘤干细胞提供了新工具。
4. **"LIFR as a Biomarker in Pancreatic Cancer: Antibody-Based Detection"**
*作者：Li X, et al.*
摘要：开发了一种高灵敏度LIFR抗体检测方法，发现LIFR在胰腺癌组织中的高表达与患者预后不良相关，抗体在ELISA和免疫荧光中验证了临床样本的可靠性。
(提示：实际文献需通过PubMed/Google Scholar检索关键词“LIFR antibody”“LIFR cancer”等获取。)
Leukemia inhibitory factor receptor (LIFR) is a transmembrane protein belonging to the interleukin-6 (IL-6) receptor family. It forms a heterodimer with glycoprotein 130 (gp130) to mediate signaling of LIF and other cytokines like oncostatin M (OSM). LIFR plays critical roles in embryonic development, hematopoiesis, nervous system maintenance, and bone metabolism through activation of JAK/STAT, MAPK, and PI3K/Akt pathways. Dysregulation of LIFR signaling is linked to skeletal disorders, cancer progression, and reproductive abnormalities.
LIFR antibodies are essential tools for studying its expression patterns, molecular interactions, and functional roles. They enable detection of LIFR in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. Research using these antibodies has revealed LIFR's dual role in cancer – acting as a metastasis suppressor in breast cancer while potentially promoting tumor growth in other contexts. Recent studies also highlight its importance in maintaining stem cell pluripotency and regulating bone remodeling through osteoblast-osteoclast crosstalk. The development of specific LIFR antibodies continues to support investigations into its therapeutic potential for bone diseases, fertility disorders, and cancer treatment strategies.
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