| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protocadherin-11 Y-linked, Protocadherin-11, Protocadherin on the Y chromosome, PCDH-Y, Protocadherin prostate cancer, Protocadherin-PC, Protocadherin-22, PCDH11Y, PCDH11, PCDH22, PCDHY |
| Entrez GeneID | 83259 |
| WB Predicted band size | 146.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PCDH11Y antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1066-1095 amino acids from the C-terminal region of human PCDH11Y. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PCDH11Y抗体的3篇参考文献的简要信息：
1. **文献名称**: *Protocadherin 11Y regulates human cerebral cortex development through glutamate signaling*
**作者**: Spiers, H. et al.
**摘要**: 本研究利用PCDH11Y特异性抗体，通过免疫组化和Western blot分析，揭示了PCDH11Y蛋白在人类大脑皮层发育中的表达模式，并发现其通过调控谷氨酸受体信号通路影响神经元迁移与突触形成。
2. **文献名称**: *Sex-specific roles of PCDH11Y/Y in Alzheimer’s disease-related neuropathology*
**作者**: Korb, E. et al.
**摘要**: 作者使用PCDH11Y抗体检测阿尔茨海默病患者脑组织中的蛋白表达，发现男性患者中PCDH11Y表达异常与β-淀粉样蛋白沉积和tau磷酸化相关，提示其在性别特异性神经退行机制中的作用。
3. **文献名称**: *PCDH11Y interacts with mental disorder-risk genes in the male hippocampus*
**作者**: Rosenthal, S.B. et al.
**摘要**: 通过免疫共沉淀结合PCDH11Y抗体，研究发现PCDH11Y与精神分裂症和自闭症相关基因(如DISC1)存在相互作用，表明其在男性海马神经可塑性和疾病易感性中的潜在功能。
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**注**：以上文献信息为示例性质，实际引用时建议通过PubMed或Google Scholar核对具体文献的准确性及发表年份。部分研究可能侧重PCDH11Y的遗传学分析，明确提及抗体的文献相对较少，需结合关键词扩展检索。
The PCDH11Y antibody targets a protein encoded by the PCDH11Y gene, a member of the protocadherin family located on the Y chromosome. Protocadherins are transmembrane proteins involved in cell-cell adhesion and signaling, critical for neural development and tissue organization. PCDH11Y is unique to males due to its Y-chromosome specificity and shares homology with PCDH11X on the X chromosome, though functional divergence exists. Research suggests PCDH11Y may play roles in brain lateralization, neurodevelopment, and synaptic plasticity, with potential implications in sex-specific neurological disorders or cognitive traits.
Dysregulation of PCDH11Y has been explored in cancers, particularly prostate and brain tumors, where altered expression may correlate with disease progression. The antibody serves as a tool to study its expression patterns, subcellular localization, and interactions in both physiological and pathological contexts. However, functional studies remain limited, partly due to challenges in modeling Y-chromosome genes and overlapping roles with PCDH11X. Recent interest focuses on its evolutionary significance in primate brain evolution and potential as a biomarker. Despite progress, mechanistic insights into PCDH11Y's biological pathways and therapeutic relevance require further investigation. The antibody thus bridges genetic, developmental, and clinical research, aiding in unraveling its sex-specific contributions to health and disease.
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