Rabbit Polyclonal ONECUT3 Antibody

The ONECUT3 antibody is a research tool designed to detect and study the ONECUT3 protein, a member of the ONECUT (also known as HNF6) transcription factor family. These proteins are characterized by a conserved single-cut domain and a homeodomain, enabling DNA binding and regulation of target genes. ONECUT3. encoded by the *ONECUT3* gene in humans, plays critical roles in embryonic development, tissue differentiation, and metabolic regulation, particularly in the liver, pancreas, and nervous system. It is implicated in maintaining cellular identity and function, with studies linking its dysregulation to diseases such as diabetes, liver fibrosis, and cancers (e.g., hepatocellular carcinoma). Researchers use ONECUT3 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions in normal and pathological contexts. Commercial ONECUT3 antibodies are typically validated for specificity and sensitivity, often targeting epitopes within its N-terminal or C-terminal regions. Recent studies also explore its role in neuronal development and metabolic pathways, highlighting its potential as a therapeutic target. However, variability in antibody performance across experimental conditions necessitates careful validation for reproducibility. Overall, ONECUT3 antibodies are vital for elucidating the protein’s biological functions and its relevance in human health and disease.