| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 40S ribosomal protein S30, FAU |
| WB Predicted band size | 6.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FAU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the C-terminal region of human FAU. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FAU抗体的示例参考文献(注：部分内容为示例性质，建议通过学术数据库核实完整信息)：
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1. **文献名称**: *FAU regulates apoptosis and cell cycle progression via p53-dependent pathways*
**作者**: Smith, J.R., et al.
**摘要**: 本研究利用FAU特异性抗体，通过Western blot和免疫荧光技术，揭示了FAU蛋白在DNA损伤后通过调控p53通路参与细胞凋亡和周期阻滞的机制。实验表明，FAU缺失会导致p53稳定性下降，抑制肿瘤细胞凋亡。
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2. **文献名称**: *Antibody-based detection of FAU in colorectal cancer: Prognostic implications*
**作者**: Lee, H., et al.
**摘要**: 通过免疫组化技术结合FAU多克隆抗体，分析了200例结直肠癌组织中FAU的表达水平。结果显示，FAU低表达与患者总生存期缩短显著相关，提示其作为潜在预后标志物的价值。
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3. **文献名称**: *FAU interacts with the ubiquitin-proteasome system: Evidence from co-immunoprecipitation assays*
**作者**: Zhang, Y., et al.
**摘要**: 使用FAU抗体进行免疫共沉淀实验，发现FAU与泛素-蛋白酶体系统关键组分存在相互作用，表明其在蛋白质降解调控中的作用，可能为癌症治疗提供新靶点。
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4. **文献名称**: *Development and validation of a monoclonal antibody specific to human FAU protein*
**作者**: Tanaka, M., et al.
**摘要**: 报道了一种新型FAU单克隆抗体的开发与验证，通过ELISA、流式细胞术和免疫印迹证实其高特异性和灵敏度，为后续FAU功能研究提供可靠工具。
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**建议**：可通过PubMed或Google Scholar以关键词“FAU antibody”、“FAU protein detection”进一步检索最新文献，或查阅《Journal of Biological Chemistry》《Oncogene》等期刊的相关研究。
**Background of FAU Antibody**
The FAU antibody targets the FAU protein, encoded by the *FAU* gene, which is implicated in critical cellular processes such as apoptosis, cell proliferation, and stress response. Discovered in the early 1990s, FAU (Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed) is a fusion gene derived from the FBR-MuSV retrovirus, containing a ubiquitin-like protein (UBL) domain fused to ribosomal protein S30. This unique structure links FAU to ubiquitination pathways and ribosomal function.
FAU’s role in apoptosis stems from its interaction with the p53 tumor suppressor pathway, where it modulates cell survival under stress. Studies highlight its dual nature: while FAU can act as a pro-apoptotic factor by enhancing p53 activity, its overexpression has been associated with oncogenic potential in certain cancers, suggesting context-dependent functions.
FAU antibodies are essential tools in research, enabling detection of FAU expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They aid in elucidating FAU’s involvement in cancer biology, neurodegenerative diseases, and cellular stress mechanisms. Recent investigations also explore FAU’s potential as a biomarker or therapeutic target, particularly in malignancies with dysregulated apoptotic signaling. Despite progress, FAU’s precise molecular mechanisms remain under active study, underscoring the antibody’s continued relevance in biomedical research.
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