| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LIM domain-binding protein 2, LDB-2, Carboxyl-terminal LIM domain-binding protein 1, CLIM-1, LIM domain-binding factor CLIM1, LDB2, CLIM1 |
| Entrez GeneID | 9079 |
| WB Predicted band size | 42.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LDB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human LDB2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及LDB2抗体的文献摘要示例(文献名称与作者为虚构示例，仅供参考格式)：
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1. **文献名称**：*LDB2 Antibody Validation in Cardiac Development Studies*
**作者**：Smith J, et al.
**摘要**：本研究验证了LDB2特异性抗体在小鼠心脏组织中的适用性，通过免疫组化及Western blot证实其可特异性识别LDB2蛋白，并揭示其在胚胎期心脏祖细胞分化中的动态表达模式。
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2. **文献名称**：*Role of LDB2 in Neural Crest Cell Migration: Insights from Antibody-Based Inhibition*
**作者**：Lee H, et al.
**摘要**：利用抗LDB2抗体阻断实验，发现LDB2通过调控转录复合物SLUG/E-cadherin轴促进神经嵴细胞迁移，抗体特异性经敲除细胞系验证，为发育生物学提供工具支持。
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3. **文献名称**：*LDB2 Antibody Application in Colorectal Cancer Biomarker Screening*
**作者**：Garcia R, et al.
**摘要**：开发高灵敏度的LDB2单克隆抗体用于结直肠癌组织微阵列分析，发现LDB2低表达与患者预后不良相关，抗体特异性通过质谱及siRNA对照实验确认。
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4. **文献名称**：*LDB2-ChIP-seq Optimization Using a Novel Polyclonal Antibody*
**作者**：Zhang Y, et al.
**摘要**：报道一种新型LDB2多克隆抗体的开发与染色质免疫沉淀(ChIP)应用，成功解析LDB2在血管内皮细胞中调控Wnt信号通路的基因组结合位点。
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**注**：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词“LDB2 antibody”或结合具体研究领域筛选。
The LDB2 antibody targets the LIM-domain binding protein 2 (LDB2), a transcriptional co-regulator involved in diverse developmental and cellular processes. LDB2. part of the LDB protein family, lacks DNA-binding domains but interacts with LIM-homeodomain (LIM-HD) transcription factors via its LIM-interaction domain, facilitating the assembly of multi-protein complexes. These complexes regulate gene expression critical for cell differentiation, tissue development, and organogenesis, particularly in neural, cardiovascular, and skeletal systems.
LDB2 functions as a scaffold, stabilizing interactions between LIM-HD proteins (e.g., LHX2. LHX3) and other transcriptional regulators to modulate target gene activation or repression. It plays roles in axon guidance, cardiomyocyte maturation, and muscle development. Dysregulation of LDB2 is implicated in pathological conditions, including neurological disorders and cancers.
Antibodies against LDB2 are essential tools for studying its expression, localization, and interactions in vitro and in vivo. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore LDB2's mechanistic roles in development and disease. Research utilizing LDB2 antibodies has advanced understanding of transcriptional networks governing cellular identity and disease pathways, highlighting its potential as a therapeutic or diagnostic target. Commercial LDB2 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat models.
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