| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | U6 snRNA-associated Sm-like protein LSm7, LSM7 |
| Entrez GeneID | 51690 |
| WB Predicted band size | 11.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LSM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-72 amino acids from the C-terminal region of human LSM7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LSM7抗体的3篇代表性文献的简要总结(注：文献信息为模拟生成，供参考)：
1. **文献名称**：The role of LSM7 in spliceosome assembly and its interaction with snRNAs
**作者**：Chen Y et al.
**摘要**：本研究利用LSM7特异性抗体通过免疫共沉淀和RNA测序技术，揭示了LSM7蛋白在剪接体形成中的作用。实验表明LSM7通过结合U6 snRNA调控前体mRNA剪接，抗体阻断实验进一步验证了其功能依赖性。
2. **文献名称**：LSM7 as a potential biomarker in colorectal cancer: Antibody-based detection and clinical correlation
**作者**：Wang L et al.
**摘要**：通过开发高特异性LSM7单克隆抗体，研究者发现LSM7在结直肠癌组织中表达显著上调。抗体用于组织芯片免疫组化分析，证实其表达水平与患者预后不良相关，提示LSM7可能作为癌症治疗靶点。
3. **文献名称**：Autoantibody against LSM7 in systemic lupus erythematosus: Clinical significance and molecular characterization
**作者**：Kimura A et al.
**摘要**：该研究通过ELISA和蛋白质印迹发现系统性红斑狼疮(SLE)患者血清中存在抗LSM7自身抗体。使用重组LSM7蛋白及抗体验证实验表明，此类自身抗体与疾病活动度相关，为SLE诊断提供了新标志物。
4. **文献名称**：Structural insights into the LSM2-8 complex assembly using cryo-EM and antibody labeling
**作者**：García-Sastre A et al.
**摘要**：结合冷冻电镜技术和LSM7抗体的表位标记，本研究解析了LSM2-8复合体的三维结构，揭示了LSM7在维持复合体稳定性中的关键作用，为RNA代谢机制研究提供了结构基础。
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**说明**：以上文献为示例性内容，实际研究中建议通过PubMed或Web of Science以“LSM7 AND (antibody OR immuno*)”为关键词检索最新文献。重点关注涉及抗体开发、功能验证或疾病机制的研究方向。
The LSM7 antibody is a research tool used to study the LSM7 protein, a component of the LSM (Like Sm) protein family involved in RNA processing. LSM7 is part of the cytoplasmic LSM1-7 complex, which plays a critical role in mRNA decapping and degradation by recruiting enzymes to remove the 5' cap of mRNAs, marking them for exonucleolytic decay. This process is essential for regulating gene expression, quality control of aberrant transcripts, and cellular stress responses. Additionally, LSM7 interacts with the nuclear LSM2-8 complex, implicated in pre-mRNA splicing. Antibodies targeting LSM7 enable researchers to investigate its expression, localization, and interactions in various biological contexts.
LSM7 antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore its role in RNA metabolism pathways. Dysregulation of LSM7 has been linked to diseases such as cancer and neurodegenerative disorders, where mRNA stability and splicing mechanisms are perturbed. For example, altered LSM7 expression may influence tumor progression by modulating oncogene or tumor suppressor mRNA levels.
These antibodies are typically validated for specificity and affinity across species, with applications in both basic and translational research. Understanding LSM7's functions through antibody-based studies contributes to insights into post-transcriptional regulation and potential therapeutic targets for RNA-related pathologies.
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