| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-1B, RAB1B |
| Entrez GeneID | 81876 |
| WB Predicted band size | 22.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This RAB1B antibody is generated from a mouse immunized with a recombinant protein between 1-201 amino acids from human RAB1B. |
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以下是关于RAB1B抗体的3篇示例文献(文献信息为模拟，实际引用时请核实原文)：
1. **文献名称**：*"RAB1B regulates vesicular transport in cancer cell migration"*
**作者**：Zhang L, et al.
**摘要**：研究利用RAB1B抗体通过Western blot和免疫荧光技术，发现RAB1B在乳腺癌细胞中高表达，并通过调控高尔基体-内质网囊泡运输促进肿瘤细胞侵袭。
2. **文献名称**：*"Role of RAB1B in autophagosome formation during neurodegenerative disease"*
**作者**：Alvarez SE, et al.
**摘要**：通过RAB1B抗体检测发现，RAB1B与自噬相关蛋白LC3存在共定位，表明其在阿尔茨海默病模型中参与自噬体形成的早期阶段。
3. **文献名称**：*"Validation of RAB1B antibody specificity in viral replication studies"*
**作者**：Benedicto RS, et al.
**摘要**：验证了商业RAB1B抗体的特异性(如Abcam #ab12345)，并证明丙肝病毒(HCV)通过劫持RAB1B介导的囊泡运输促进自身复制。
4. **文献名称**：*"Comparative analysis of RAB1B antibody performance in immunoassays"*
**作者**：Johnson M, Smith K.
**摘要**：对比了不同来源的RAB1B抗体在IP、IF和IHC中的应用效果，推荐特定抗体用于亚细胞定位研究。
**注意**：以上为模拟文献，实际研究中需通过PubMed或Google Scholar检索真实文献(关键词：RAB1B antibody, RAB1B function)。
**Background of RAB1B Antibody**
RAB1B is a member of the RAB family of small GTPases, which regulate intracellular membrane trafficking by cycling between active (GTP-bound) and inactive (GDP-bound) states. Specifically, RAB1B plays a critical role in endoplasmic reticulum (ER)-to-Golgi transport, facilitating vesicle formation, cargo sorting, and membrane fusion. It is involved in maintaining Golgi structure, secretory pathways, and autophagy. Dysregulation of RAB1B has been linked to diseases such as cancer, neurodegenerative disorders, and infections.
RAB1B antibodies are essential tools for studying the expression, localization, and function of this protein. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect RAB1B in cell lysates or tissue samples. These antibodies help elucidate RAB1B's interaction partners, post-translational modifications (e.g., prenylation), and its role in cellular pathways. Polyclonal antibodies often provide higher sensitivity, while monoclonal antibodies offer specificity, enabling precise detection of RAB1B isoforms or phosphorylation states.
Research utilizing RAB1B antibodies has revealed its importance in pathological contexts, such as promoting tumor progression via secretory pathway activation or modulating neurodegeneration in Alzheimer’s disease. Validated antibodies are crucial to ensure reproducibility in studies exploring RAB1B's mechanistic contributions to health and disease.
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