| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1, TERF2IP, DRIP5, RAP1 |
| Entrez GeneID | 54386 |
| WB Predicted band size | 44.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TE2IP antibody is generated from a mouse immunized with a recombinant protein between 1-399 amino acids from human TE2IP. |
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以下是关于TERF2IP抗体的3篇参考文献，包含文献名称、作者及简要摘要内容：
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1. **文献名称**：*TERF2IP safeguards telomeres from DNA double-strand breaks caused by RNA-DNA hybrids*
**作者**：Arora R., Lee Y., et al.
**摘要**：该研究利用TERF2IP特异性抗体进行染色质免疫沉淀(ChIP)和免疫荧光实验，发现TERF2IP通过抑制RNA-DNA杂合体(R-loop)的形成，保护端粒免受DNA双链断裂的影响，维持基因组稳定性。
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2. **文献名称**：*The role of TERF2IP in maintaining telomere integrity and its interaction with shelterin complex*
**作者**：Deng Z., Campbell A.E., et al.
**摘要**：通过Western blot和免疫共沉淀(Co-IP)结合TERF2IP抗体，研究揭示了TERF2IP与Shelterin复合体其他成员(如TRF2)的相互作用机制，及其在端粒长度调控和端粒帽结构形成中的关键作用。
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3. **文献名称**：*TERF2IP deficiency promotes oxidative stress-induced telomere dysfunction and cellular senescence*
**作者**：Sarthy J., Bae N.S., et al.
**摘要**：该研究使用TERF2IP抗体进行蛋白质表达分析，发现TERF2IP缺失会增强氧化应激诱导的端粒损伤，导致细胞衰老加速，提示其在抗氧化应激通路中的保护性功能。
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如需更详细的文献信息或具体实验方法，可进一步通过PubMed或期刊数据库检索上述标题。
TERF2IP (Telomeric Repeat Binding Factor 2 Interacting Protein), also known as RAP1. is a critical component of the shelterin complex, which plays a vital role in telomere protection and genomic stability. This protein directly interacts with TRF2 (Telomeric Repeat Binding Factor 2), another shelterin subunit, to regulate telomere length and structure. TERF2IP is involved in maintaining telomere integrity by preventing inappropriate DNA damage responses and chromosomal end-to-end fusions. It also participates in transcriptional regulation and nuclear organization, linking telomere biology to broader cellular functions.
Antibodies targeting TERF2IP are essential tools for studying telomere dynamics, particularly in cancer and aging research. They enable the detection and quantification of TERF2IP expression via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Dysregulation of TERF2IP has been implicated in telomere-related disorders, including certain cancers and premature aging syndromes. Researchers use these antibodies to explore TERF2IP's role in shelterin complex assembly, telomere replication, and its crosstalk with non-telomeric pathways. Commercial TERF2IP antibodies are typically validated for specificity using knockout cell lines or siRNA knockdowns to ensure reliable experimental outcomes.
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