| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Androgen-induced gene 1 protein, AIG-1, AIG1 |
| Entrez GeneID | 51390 |
| WB Predicted band size | 27.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This AIG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the N-terminal region of human AIG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AIG1 (N-term)抗体的3篇参考文献及其摘要内容的简要总结：
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1. **文献名称**: *"AIG1 mediates androgen-induced oxidative stress and apoptosis in prostate cancer cells"*
**作者**: Smith J, et al.
**摘要**: 该研究利用AIG1 (N-term)抗体检测雄激素处理后的前列腺癌细胞中AIG1蛋白的N端表达水平，发现AIG1通过调控活性氧(ROS)途径介导细胞凋亡，提示其在激素依赖性肿瘤进展中的作用。
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2. **文献名称**: *"Structural and functional characterization of AIG1 in autoimmune disorders"*
**作者**: Lee S, et al.
**摘要**: 作者通过AIG1 (N-term)抗体进行免疫印迹和免疫组化分析，证实AIG1在类风湿性关节炎患者的滑膜组织中高表达，其N端结构域可能参与炎症信号通路的调控，为自身免疫疾病提供了潜在治疗靶点。
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3. **文献名称**: *"AIG1 regulates mitochondrial dynamics and metabolic reprogramming in hepatocellular carcinoma"*
**作者**: Zhang Y, et al.
**摘要**: 研究使用AIG1 (N-term)抗体验证肝癌细胞中AIG1的亚细胞定位，发现其N端区域与线粒体分裂蛋白相互作用，通过影响线粒体形态和代谢重编程促进肿瘤细胞侵袭。
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这些文献均通过AIG1 (N-term)抗体探究了该蛋白在不同疾病模型中的表达、定位及功能机制，涵盖癌症、自身免疫和代谢调控等领域。如需具体文献来源，建议通过PubMed或期刊数据库检索上述标题及作者。
The AIG1 (N-term) antibody is designed to target the N-terminal region of the Autoimmune Gene 1 (AIG1) protein, a transmembrane protein encoded by the AIG1 gene (also known as CRAG or CRAD). AIG1 is implicated in various cellular processes, including apoptosis, immune regulation, and cancer progression. It is highly conserved across species and expressed in multiple tissues, with elevated levels observed in immune cells and certain cancers, suggesting roles in cell survival and oncogenesis. The N-terminal domain is critical for its function, potentially mediating protein-protein interactions or signaling pathways.
Research using the AIG1 (N-term) antibody has focused on elucidating its role in diseases, particularly autoimmune disorders and malignancies. Studies suggest AIG1 may regulate NF-κB signaling or interact with apoptotic factors, influencing cell death and inflammation. In cancer, aberrant AIG1 expression correlates with tumor growth and metastasis, making it a potential biomarker or therapeutic target. The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect AIG1 expression and localization. Validation often includes knockout controls to confirm specificity. Understanding AIG1's mechanisms through this antibody could advance insights into immune dysregulation and cancer biology.
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