| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/100 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial peptide methionine sulfoxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase, Protein-methionine-S-oxide reductase, PMSR, MSRA |
| Entrez GeneID | 4482 |
| WB Predicted band size | 26.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MSRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 amino acids from the N-terminal region of human MSRA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于MSRA(N-term)抗体的3篇示例文献(内容为模拟示例，具体文献请通过学术数据库查询)：
1. **文献名称**：*"Characterization of a Novel Monoclonal Antibody Targeting the N-terminal Domain of Methionine Sulfoxide Reductase A"*
**作者**：Smith J, et al.
**摘要**：研究报道了一种特异性识别MSRA蛋白N端表位的单克隆抗体，验证了其在Western blot和免疫荧光中的应用，并证明其在氧化应激模型中检测MSRA表达变化的敏感性。
2. **文献名称**：*"Role of MSRA in Neuronal Protection: Insights from N-terminal Specific Antibody Staining"*
**作者**：Chen L, et al.
**摘要**：通过使用N端特异性抗体，研究发现MSRA在阿尔茨海默病模型小鼠脑组织中表达下调，提示其抗氧化功能可能与神经保护相关。
3. **文献名称**：*"Structural and Functional Analysis of MSRA Using Domain-Specific Antibodies"*
**作者**：Wang Y, et al.
**摘要**：该研究利用针对MSRA不同结构域(包括N端)的抗体进行免疫共沉淀实验，揭示了N端结构域在酶活性调控中的关键作用。
**建议**：可通过PubMed、Web of Science等平台，以关键词“MSRA antibody N-terminal”“Methionine Sulfoxide Reductase A epitope”检索最新文献。部分工具如CiteAb还能查询抗体在论文中的使用记录。
MSRA (methylmalonate-semialdehyde dehydrogenase), also known as ALDH6A1. is a mitochondrial enzyme involved in valine, thymine, and propionyl-CoA catabolism, playing a critical role in cellular metabolism. The MSRA (N-term) antibody is specifically designed to target the N-terminal region of the MSRA protein, enabling the detection and study of its expression, localization, and function. This antibody is commonly utilized in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate MSRA's involvement in metabolic pathways and disease contexts.
MSRA catalyzes the NAD-dependent conversion of methylmalonate semialdehyde to acetyl-CoA, linking amino acid and fatty acid metabolism with the tricarboxylic acid cycle. Dysregulation of MSRA has been associated with metabolic disorders, mitochondrial dysfunction, and cancer progression. Researchers employ the MSRA (N-term) antibody to explore its role in these conditions, as well as in developmental biology and cellular stress responses. The antibody's specificity for the N-terminal region ensures recognition of full-length, endogenous MSRA, distinguishing it from degradation products or splice variants. Its development has facilitated mechanistic studies into how MSRA deficiency contributes to rare genetic disorders like methylmalonic aciduria and broader metabolic syndromes. By enabling precise protein analysis, this tool supports advances in understanding mitochondrial metabolism and its implications for human health.
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