| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor MafF, U-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog F, MAFF |
| Entrez GeneID | 23764 |
| WB Predicted band size | 17.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MAFF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-92 amino acids from the Central region of human MAFF. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于MAFF抗体的3篇参考文献示例(内容为模拟概括，非真实文献)：
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1. **文献名称**：*MAFF as a Biomarker for Chemoresistance in Hepatocellular Carcinoma*
**作者**：Zhang Y et al.
**摘要**：本研究通过Western blot和免疫组化技术，利用特异性MAFF抗体检测肝癌组织中MAFF蛋白表达，发现其高表达与化疗耐药性显著相关。机制研究表明MAFF通过调控抗氧化通路促进肿瘤细胞存活。
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2. **文献名称**：*Immunohistochemical Analysis of MAFF in Gastric Cancer Progression*
**作者**：Kim S et al.
**摘要**：作者采用MAFF抗体对胃癌患者组织样本进行染色，发现MAFF蛋白在晚期肿瘤中显著上调，且与淋巴结转移及预后不良相关，提示其可作为胃癌进展的潜在标志物。
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3. **文献名称**：*MAFF Antibody Reveals Its Role in Neuronal Oxidative Stress Response*
**作者**：Chen L et al.
**摘要**：通过免疫荧光和流式细胞术，该研究利用MAFF抗体证实神经元在氧化应激下MAFF蛋白核内聚集，激活下游抗氧化基因，为神经退行性疾病机制提供新见解。
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4. **文献名称**：*Generation and Validation of a Novel MAFF-Specific Monoclonal Antibody*
**作者**：Sato R et al.
**摘要**：本文报道了一种新型MAFF单克隆抗体的开发，通过ELISA、免疫沉淀和质谱验证其特异性，成功应用于小鼠胚胎发育模型中MAFF蛋白的时空表达分析。
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注：以上文献为示例，实际引用需查询真实数据库(如PubMed)。如需进一步扩展领域或补充具体研究细节，可调整关键词检索。
MAFF (Musculoaponeurotic Fibrosarcoma Oncogene Family Protein F) is a member of the MAF family of basic leucine zipper (bZIP) transcription factors. Discovered in the 1990s, MAFF regulates gene expression by forming homodimers or heterodimers with other bZIP proteins, such as NRF2. to bind antioxidant response elements (AREs) in DNA. It plays a critical role in cellular defense mechanisms against oxidative and electrophilic stress through the Keap1-Nrf2-ARE pathway. MAFF is involved in diverse biological processes, including inflammation, differentiation, and apoptosis.
MAFF antibodies are essential tools for studying its expression, localization, and interactions in various tissues. They enable detection via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Research highlights MAFF's dual role: it can act as a tumor suppressor by promoting detoxification and redox homeostasis, but its overexpression is linked to cancer progression, chemoresistance, and poor prognosis in malignancies like hepatocellular carcinoma and glioblastoma. Dysregulation of MAFF is also implicated in neurodegenerative diseases and metabolic disorders.
These antibodies aid in exploring MAFF's context-dependent functions, therapeutic targeting potential, and crosstalk with signaling pathways like MAPK/ERK. Commercial MAFF antibodies are typically validated for specificity in human, mouse, or rat models, supporting both basic research and clinical biomarker studies.
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