| WB | 1/1000-1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Methylosome subunit pICln, Chloride channel, nucleotide sensitive 1A, Chloride conductance regulatory protein ICln, I(Cln), Chloride ion current inducer protein, ClCI, Reticulocyte pICln, CLNS1A, CLCI, ICLN |
| Entrez GeneID | 1207 |
| WB Predicted band size | 26.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CLNS1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-216 amino acids from the C-terminal region of human CLNS1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于CLNS1A抗体的参考文献示例(注：以下文献为假设性示例，仅供参考，实际文献需通过学术数据库验证)：
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1. **文献名称**: "CLNS1A Antibody Validation and Its Role in Splicing Complex Assembly"
**作者**: Smith J, et al.
**摘要**: 本研究验证了CLNS1A抗体的特异性，通过免疫共沉淀和质谱分析，证明CLNS1A是剪接体U5 snRNP复合体的关键组分，参与pre-mRNA剪接的调控。
2. **文献名称**: "CLNS1A Expression Correlates with Cellular Stress Response in Neurodegenerative Models"
**作者**: Lee H, et al.
**摘要**: 利用CLNS1A抗体进行免疫荧光和Western blot，发现CLNS1A在神经元应激条件下表达上调，可能通过调节离子稳态影响神经退行性疾病的病理过程。
3. **文献名称**: "Development of a Monoclonal CLNS1A Antibody for Cancer Biomarker Studies"
**作者**: Wang X, et al.
**摘要**: 报道了一种高特异性的CLNS1A单克隆抗体的开发，并应用于肝癌组织芯片分析，发现CLNS1A低表达与肿瘤转移和患者生存率降低显著相关。
4. **文献名称**: "CLNS1A Interaction with Chloride Channels in Epithelial Cells"
**作者**: García-Rojas M, et al.
**摘要**: 通过免疫沉淀和功能实验，揭示了CLNS1A与上皮细胞氯离子通道蛋白(如CLIC1)的相互作用，提示其在细胞体积调节中的潜在作用。
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**建议**：如需真实文献，请通过PubMed或Google Scholar以关键词 **"CLNS1A antibody"** 或 **"CLNS1A function"** 检索，并筛选涉及抗体应用、蛋白功能或疾病机制的研究。
The CLNS1A antibody targets the CLNS1A protein, encoded by the *CLNS1A* gene, which plays a role in sphingosine-1-phosphate (S1P) metabolism. CLNS1A is a regulatory subunit of the sphingosine-1-phosphate lyase (SGPL1) complex, critical for degrading S1P—a bioactive lipid involved in cell proliferation, apoptosis, and immune response regulation. Dysregulation of S1P signaling is linked to cancer, inflammation, and autoimmune diseases, making CLNS1A a focus in metabolic and disease research.
CLNS1A antibodies are typically developed as polyclonal or monoclonal reagents, often raised against specific peptide sequences or recombinant protein fragments. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CLNS1A expression, localization, and interaction partners. Researchers employ these antibodies to explore CLNS1A’s role in maintaining S1P homeostasis, its impact on cellular signaling pathways, and its potential as a therapeutic target. In disease contexts, such as cancer or neurodegenerative disorders, CLNS1A antibodies help elucidate molecular mechanisms and validate biomarkers. Validation steps, including knockout controls and specificity assays, ensure reliability in experimental models. Overall, CLNS1A antibodies are vital tools for advancing understanding of sphingolipid biology and related pathologies.
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