| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Actin-related protein 2/3 complex subunit 1A, SOP2-like protein, ARPC1A, SOP2L |
| Entrez GeneID | 10552 |
| WB Predicted band size | 41.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ARPC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of human ARPC1A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于ARPC1A抗体的参考文献示例(注：以下内容为模拟虚构，仅供参考)：
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1. **文献名称**: "ARPC1A regulates actin cytoskeleton organization in cancer cell invasion"
**作者**: Smith J, et al.
**摘要**: 本研究利用ARPC1A特异性抗体，通过免疫印迹和免疫荧光技术，揭示了ARPC1A在乳腺癌细胞迁移和侵袭中的关键作用。研究发现，ARPC1A表达水平与肌动蛋白分支结构的形成密切相关，抑制其功能可显著降低癌细胞转移能力。
2. **文献名称**: "Genetic ablation of ARPC1A disrupts T cell polarization and immune synapse formation"
**作者**: Lee H, et al.
**摘要**: 作者通过CRISPR-Cas9敲除ARPC1A基因，并结合ARPC1A抗体进行流式细胞术分析，证明该蛋白在T细胞极化和免疫突触组装中不可或缺。研究为ARPC1A在免疫调节中的机制提供了新见解。
3. **文献名称**: "ARPC1A antibody-based profiling identifies dysregulation in neurodevelopmental disorders"
**作者**: Chen R, et al.
**摘要**: 本研究开发了一种高特异性ARPC1A多克隆抗体，用于分析自闭症患者脑组织样本。结果显示，ARPC1A表达异常与神经元突触结构缺陷相关，提示其在神经发育中的潜在病理作用。
4. **文献名称**: "Role of ARPC1A in podocyte architecture and glomerular disease pathogenesis"
**作者**: Gupta S, et al.
**摘要**: 通过ARPC1A抗体进行免疫组化染色，研究发现肾小球足细胞中ARPC1A的缺失导致肌动蛋白骨架紊乱，进而引发蛋白尿和肾小球硬化，为慢性肾病提供了新的治疗靶点。
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建议通过PubMed、Google Scholar等平台以“ARPC1A antibody”或“ARPC1A function”为关键词检索真实文献。
The ARPC1A antibody targets the Actin-Related Protein 2/3 Complex Subunit 1A (ARPC1A), a key component of the ARP2/3 complex, which regulates actin polymerization and cytoskeletal dynamics. The ARP2/3 complex, comprising seven subunits (ARP2. ARP3. and ARPC1-5), plays a critical role in nucleating branched actin networks essential for cell motility, membrane protrusion, vesicular trafficking, and cell division. ARPC1A, one of two paralogs (ARPC1A and ARPC1B), is ubiquitously expressed but shows tissue-specific variation, with higher levels in immune cells and certain epithelial tissues.
ARPC1A antibodies are widely used to study cytoskeletal organization and its dysregulation in diseases like cancer, immune disorders, and neurological conditions. These antibodies enable detection of ARPC1A expression via techniques such as Western blotting, immunofluorescence, and immunohistochemistry, aiding in investigations of cell migration, invasion, and metastatic potential in tumors. Studies also link ARPC1A mutations or altered expression to immune deficiencies and neurodevelopmental disorders, highlighting its broader physiological relevance.
Commercial ARPC1A antibodies are typically validated for specificity against recombinant proteins or knockout cell lines to ensure minimal cross-reactivity with ARPC1B. Researchers utilize these tools to explore functional redundancy or divergence between ARPC1 paralogs and their roles in actin-dependent processes, offering insights into therapeutic targeting of cytoskeletal pathways.
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