| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adenylate cyclase type 10, AH-related protein, Adenylate cyclase homolog, Germ cell soluble adenylyl cyclase, hsAC, sAC, Testicular soluble adenylyl cyclase, ADCY10, SAC |
| Entrez GeneID | 55811 |
| WB Predicted band size | 18.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADCY10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-583 amino acids from the Central region of human ADCY10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及ADCY10(可溶性腺苷酸环化酶，sAC)抗体的参考文献摘要：
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1. **文献名称**: *"Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor"*
**作者**: Buck J, Sinclair ML, Levin LR.
**摘要**: 该研究利用ADCY10特异性抗体，通过免疫印迹和免疫荧光技术，首次证实sAC在哺乳动物精子中作为pH/碳酸氢盐传感器的功能，揭示了其在调控精子活力中的关键作用。
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2. **文献名称**: *"Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains"*
**作者**: Zippin JH, Farrell J, Huron D, et al.
**摘要**: 作者通过ADCY10抗体进行亚细胞定位分析，发现sAC在线粒体和细胞核周围存在特异性分布，表明其通过调控局部cAMP水平参与细胞能量代谢与基因表达调控。
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3. **文献名称**: *"Role of soluble adenylyl cyclase in cAMP signaling and insulin secretion in pancreatic β-cells"*
**作者**: Schmid A, Meili D, Saba A.
**摘要**: 研究采用ADCY10抗体抑制实验，证明sAC在胰岛β细胞中响应葡萄糖刺激，调控胰岛素分泌，为糖尿病治疗提供了潜在分子靶点。
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**备注**：若需获取全文，建议通过PubMed(https://pubmed.ncbi.nlm.nih.gov)或期刊官网输入标题或作者查询。部分文献可能需要订阅权限。
**Background of ADCY10 Antibody**
Adenylyl cyclase 10 (ADCY10), also known as soluble adenylyl cyclase (sAC), is a unique member of the adenylate cyclase family that catalyzes the conversion of ATP to cyclic AMP (cAMP), a critical secondary messenger in cellular signaling. Unlike transmembrane adenylyl cyclases, ADCY10 is primarily localized in the cytoplasm, mitochondria, and nucleus, and its activity is regulated by bicarbonate and calcium ions rather than G-protein-coupled receptors. This makes it a key player in diverse physiological processes, including sperm motility, mitochondrial respiration, and pH regulation.
ADCY10 antibodies are essential tools for studying the expression, localization, and function of this enzyme in various tissues and disease contexts. Research has linked ADCY10 dysregulation to conditions such as male infertility, cancer metastasis, and metabolic disorders. For example, its role in mitochondrial cAMP signaling has implications in energy homeostasis and apoptosis.
These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ADCY10 in biological samples. Specificity and validation across species (human, mouse, rat) are critical for reliable data. Recent studies also explore ADCY10 as a therapeutic target, driving demand for high-quality antibodies to further unravel its pathophysiological mechanisms and potential clinical applications.
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