| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lactosylceramide alpha-2,3-sialyltransferase, CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase, Ganglioside GM3 synthase, ST3Gal V, ST3GalV, Sialyltransferase 9, ST3GAL5, SIAT9 |
| Entrez GeneID | 8869 |
| WB Predicted band size | 48.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ST3GAL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-418 amino acids of human ST3GAL5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与 **ST3GAL5抗体** 相关的研究文献摘要，按规范格式整理：
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1. **文献名称**：*ST3GAL5-mediated ganglioside biosynthesis promotes tumorigenesis in breast cancer via EGFR signaling*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化(IHC)和Western blot分析，发现ST3GAL5在乳腺癌组织中高表达，其通过调控神经节苷脂GD3的合成激活EGFR信号通路，促进肿瘤增殖和转移。使用特异性ST3GAL5抗体验证了其在临床样本中的表达与患者预后不良相关。
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2. **文献名称**：*Role of ST3GAL5 in regulating neuronal apoptosis and its implications in Alzheimer's disease*
**作者**：Chen L, et al.
**摘要**：通过免疫荧光和流式细胞术，研究发现ST3GAL5在小鼠脑组织中的表达下调与β-淀粉样蛋白(Aβ)沉积导致的神经元凋亡相关。特异性ST3GAL5抗体用于检测阿尔茨海默病模型中的酶活性变化，提示其可能成为治疗靶点。
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3. **文献名称**：*ST3GAL5 as a potential biomarker for immunotherapy response in melanoma*
**作者**：Rodriguez M, et al.
**摘要**：利用抗ST3GAL5抗体进行流式细胞分选和ELISA检测，发现黑色素瘤患者中ST3GAL5高表达与PD-1抑制剂治疗耐药性相关。研究揭示了ST3GAL5通过调节肿瘤细胞表面糖基化修饰影响免疫检查点阻断疗效的机制。
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**注**：以上文献为示例性质，实际引用需根据具体研究需求检索PubMed或Web of Science获取完整信息。
The ST3GAL5 antibody targets the ST3 beta-galactoside alpha-2.3-sialyltransferase 5. an enzyme encoded by the *ST3GAL5* gene. This enzyme, also known as GM3 synthase, catalyzes the transfer of sialic acid to lactosylceramide, forming GM3 ganglioside—a critical component of cell membranes and lipid rafts. GM3 plays roles in cell adhesion, signal transduction, and immune regulation. ST3GAL5 is highly expressed in the brain, where it contributes to neural development and synaptic function, but it is also implicated in cancers, metabolic disorders, and neurodegenerative diseases.
Antibodies against ST3GAL5 are used to study its expression patterns, subcellular localization, and functional roles in both physiological and pathological contexts. For example, altered ST3GAL5 activity has been linked to disrupted ganglioside profiles in Tay-Sachs disease, while its overexpression in certain cancers correlates with tumor progression and immune evasion. Researchers utilize these antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore mechanisms underlying diseases or potential therapeutic targets.
Commercial ST3GAL5 antibodies are typically validated for specificity and sensitivity across species (human, mouse, rat), though epitope differences may require validation for experimental models. Understanding ST3GAL5's role in glycosphingolipid metabolism continues to drive interest in its antibody tools for biomedical research.
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