| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Loss of heterozygosity 12 chromosomal region 1 protein, LOH12CR1 |
| Entrez GeneID | 118426 |
| WB Predicted band size | 22.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LOH12CR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the C-terminal region of human LOH12CR1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LOH12CR1抗体的3篇参考文献的简要概括(基于模拟生成，非真实文献)：
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1. **文献名称**: *"LOH12CR1 as a tumor suppressor in neuroblastoma: Antibody development and expression analysis"*
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对LOH12CR1蛋白的特异性抗体，用于检测神经母细胞瘤中该基因的缺失表达。实验表明，LOH12CR1在12p染色体缺失的肿瘤样本中表达显著降低，提示其可能作为肿瘤抑制因子参与癌症进展。
2. **文献名称**: *"Functional characterization of LOH12CR1 in lung adenocarcinoma using monoclonal antibodies"*
**作者**: Chen L, et al.
**摘要**: 作者通过构建LOH12CR1单克隆抗体，发现其在肺腺癌细胞系中调控细胞周期和凋亡的功能。抗体免疫染色结果显示，LOH12CR1低表达与患者预后不良相关，提示其临床潜在生物标志物价值。
3. **文献名称**: *"Antibody-based detection of LOH12CR1 in colorectal cancer: Implications for metastasis suppression"*
**作者**: Garcia R, et al.
**摘要**: 利用LOH12CR1多克隆抗体，研究发现该蛋白在结直肠癌转移组织中表达缺失，并通过体外实验验证其抑制侵袭转移的作用，揭示了LOH12CR1在肿瘤转移中的潜在机制。
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**说明**：以上文献为示例性内容，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。若需具体文章，建议结合关键词如“LOH12CR1 antibody”或“12p deletion antibody”进一步查询。
The LOH12CR1 antibody targets a protein encoded by the *LOH12CR1* gene (Loss of Heterozygosity 12 Chromosomal Region 1), located on human chromosome 12p12.3. This region is frequently associated with allelic loss in various cancers, including lung, ovarian, and breast cancers, suggesting a potential tumor suppressor role. The *LOH12CR1* gene spans approximately 20 kb and encodes a protein of unknown precise function, though it is hypothesized to participate in DNA repair, cell cycle regulation, or apoptosis due to its chromosomal context and expression patterns.
The LOH12CR1 antibody is primarily utilized in research to study protein expression, localization, and its potential role in carcinogenesis. It has been employed in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to analyze tissue samples, particularly in cancer research. Studies using this antibody have explored correlations between LOH12CR1 protein downregulation and tumor progression, metastasis, or poor prognosis. Its development and application contribute to understanding molecular mechanisms underlying chromosomal instability in cancer and may aid in identifying diagnostic or prognostic biomarkers. Further research is needed to fully elucidate its biological functions and therapeutic relevance.
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