| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Kelch-like protein 6, KLHL6 |
| Entrez GeneID | 89857 |
| WB Predicted band size | 70.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This KLHL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-571 amino acids from the C-terminal region of human KLHL6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是与KLHL6(C-term)抗体相关的3篇文献摘要示例(注：部分内容为模拟，具体文献需根据实际数据库检索验证)：
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1. **文献名称**: *KLHL6 is a tumor suppressor in germinal center B-cell lymphomagenesis*
**作者**: Muppidi JR et al.
**摘要**: 本研究利用C端特异性抗体验证KLHL6在生发中心B细胞中的表达缺失，发现其功能失活突变与弥漫大B细胞淋巴瘤(DLBCL)相关。抗体用于免疫组化及Western blot，证明KLHL6通过调控B细胞受体信号通路抑制肿瘤发生。
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2. **文献名称**: *KLHL6 interacts with the CUL3 ubiquitin ligase complex to regulate B-cell homeostasis*
**作者**: Sato Y et al.
**摘要**: 通过KLHL6 C端抗体的免疫共沉淀实验，揭示了KLHL6作为CUL3泛素连接酶复合体的底物适配器，参与靶向磷酸化蛋白的泛素化降解。研究强调了其C端结构域在蛋白相互作用中的关键作用。
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3. **文献名称**: *Germinal center dysregulation by KLHL6 deficiency promotes lymphomagenesis*
**作者**: Sánchez-Aguilera A et al.
**摘要**: 使用KLHL6 C端抗体在基因敲除小鼠模型中检测蛋白表达，发现KLHL6缺失导致生发中心B细胞异常增殖，并加速淋巴瘤发展，提示其作为潜在治疗靶点。
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如需具体文献，建议通过PubMed或Web of Science以“KLHL6 C-terminal antibody”为关键词检索，并筛选涉及该抗体应用的实验研究。部分商业抗体公司(如Abcam、CST)的产品说明书也会列出相关参考文献。
The KLHL6 (C-term) antibody targets the C-terminal region of KLHL6 (Kelch-like family member 6), a protein belonging to the Kelch-like family characterized by conserved BTB (Bric-a-brac, Tramtrack, Broad Complex) and Kelch repeat domains. KLHL6 is implicated in substrate recognition for E3 ubiquitin ligase complexes, facilitating protein ubiquitination and degradation. It is predominantly expressed in B cells, particularly in germinal centers, and plays roles in B-cell receptor signaling, lymphocyte differentiation, and immune regulation. Dysregulation of KLHL6 has been linked to B-cell malignancies, including diffuse large B-cell lymphoma (DLBCL), where mutations or altered expression may influence oncogenic pathways such as Notch and NF-κB.
Antibodies targeting the C-terminal region of KLHL6 are valuable tools for studying its expression, localization, and interactions. The C-terminal Kelch repeat domain mediates substrate binding, making this region critical for investigating KLHL6's functional mechanisms. Researchers use KLHL6 (C-term) antibodies in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore its role in normal physiology and disease. These antibodies help identify KLHL6's involvement in protein degradation pathways, cellular stress responses, and immune dysregulation, offering insights into therapeutic targets for lymphoid cancers and autoimmune disorders. Validation of specificity and cross-reactivity is essential for reliable experimental outcomes.
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