Rabbit Polyclonal TMEM111(N-term) Antibody

The TMEM111 (N-term) antibody is designed to target the N-terminal region of transmembrane protein 111 (TMEM111), a conserved, ubiquitously expressed protein localized primarily in the endoplasmic reticulum (ER) and Golgi apparatus. TMEM111 is implicated in intracellular vesicular trafficking, membrane dynamics, and ER-Golgi transport processes. Its structural features, including multiple transmembrane domains, suggest a role in maintaining organelle integrity or regulating protein sorting. The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study TMEM111 expression, subcellular localization, and interactions in diverse biological contexts. Research has explored its potential involvement in cellular stress responses, autophagy, and diseases such as cancer or neurodegenerative disorders, though its precise molecular mechanisms remain under investigation. Validated for specificity in multiple species, the N-terminal-targeting antibody helps distinguish TMEM111 from homologous proteins and enables functional studies, including knockdown validation or pathway analysis. Its application aids in elucidating TMEM111's contribution to secretory pathways, organelle homeostasis, and disease-associated dysregulation.