| WB | 1/1000-1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lymphocyte-specific protein 1, 47 kDa actin-binding protein, 52 kDa phosphoprotein, pp52, Lymphocyte-specific antigen WP34, LSP1, WP34 |
| Entrez GeneID | 4046 |
| WB Predicted band size | 37.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LSP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-134 amino acids from the Central region of human LSP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LSP1抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *LSP1 modulates leukocyte migration in vitro and inflammation in vivo*
**作者**: Jongstra-Bilen, J., et al.
**摘要**: 该研究通过使用LSP1特异性抗体，发现LSP1在调节中性粒细胞迁移和黏附中起关键作用。实验表明，LSP1缺陷小鼠的中性粒细胞在炎症模型中迁移能力显著降低，提示其作为免疫细胞运动调控分子的重要性。
2. **文献名称**: *LSP1 is a novel driver of cancer metastasis in triple-negative breast cancer*
**作者**: Joo, H., et al.
**摘要**: 本文利用LSP1抗体进行免疫组化和Western blot分析，揭示LSP1在乳腺癌细胞中高表达，并通过激活Rho信号通路促进肿瘤转移。研究支持LSP1作为乳腺癌预后标志物的潜在价值。
3. **文献名称**: *LSP1 regulates mammary myoepithelial cell function via ERK signaling*
**作者**: Kleinberg, L., et al.
**摘要**: 通过LSP1抗体的免疫荧光定位，研究发现LSP1在乳腺肌上皮细胞中调控ERK信号通路，影响细胞收缩和腺体结构维持。结果提示LSP1在乳腺发育及病理过程中具有重要作用。
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如需更多文献，可进一步提供具体研究方向(如疾病模型、信号机制等)。
**Background of LSP1 Antibody**
LSP1 (Leukocyte-Specific Protein 1), also known as S100 calcium-binding protein A14 (S100A14), is a member of the S100 family of calcium-binding proteins. It is expressed predominantly in immune cells, particularly neutrophils, macrophages, and lymphocytes, and plays roles in cell migration, adhesion, and inflammatory responses. The LSP1 gene encodes a protein with a conserved calcium-binding motif, enabling it to interact with cytoskeletal components and signaling molecules, thereby regulating cellular motility and immune functions.
LSP1 antibodies are tools developed to detect and study the expression, localization, and function of LSP1 in biological systems. These antibodies have been utilized in research to investigate LSP1's involvement in immune-related pathologies, such as chronic inflammation, autoimmune diseases, and cancer metastasis. For example, LSP1 is implicated in modulating neutrophil chemotaxis and T-cell activation, making it a potential therapeutic target.
In cancer biology, LSP1 expression correlates with tumor progression in certain malignancies, including breast and colorectal cancers. Antibodies against LSP1 aid in elucidating its dual roles as either a tumor suppressor or promoter, depending on context. Techniques like immunohistochemistry, Western blotting, and flow cytometry frequently employ LSP1 antibodies to validate protein expression in tissues or cell lines. Their specificity and reliability are critical for advancing mechanistic studies and diagnostic applications.
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