| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1, 2.3.1.-, LPGAT1, FAM34A, KIAA0205 |
| Entrez GeneID | 9926 |
| WB Predicted band size | 43.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LPGAT1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 144-177 amino acids from the Central region of human LPGAT1. |
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以下是3篇与LPGAT1抗体相关的文献概览(基于模拟数据，建议通过学术数据库验证具体文献)：
1. **文献名称**：LPGAT1 regulates phospholipid metabolism and liver function in mice
**作者**：Chen X, et al.
**摘要**：研究利用LPGAT1基因敲除小鼠模型，通过Western blot和免疫组化(使用兔源多克隆LPGAT1抗体)发现该酶缺失导致肝脏甘油三酯累积，揭示LPGAT1在肝脏脂质重塑中的关键作用。
2. **文献名称**：Characterization of lysophosphatidylglycerol acyltransferase 1 (LPGAT1) enzymatic activity
**作者**：Yamamoto K, et al.
**摘要**：通过体外酶活性实验结合抗体验证(小鼠单克隆LPGAT1抗体)，证实LPGAT1特异性催化溶血磷脂酰甘油的酰基化，并发现其底物偏好性与膜磷脂多样性相关。
3. **文献名称**：LPGAT1-mediated lipid signaling promotes tumor metastasis in colorectal cancer
**作者**：Wang L, et al.
**摘要**：利用免疫荧光(人源特异性LPGAT1抗体)和CRISPR干扰技术，证明LPGAT1通过调控细胞膜磷脂组成激活ERK通路，促进结直肠癌侵袭，提示其作为潜在治疗靶点。
*注：以上为模拟示例，实际文献需通过PubMed/Google Scholar检索确认。建议使用关键词"LPGAT1 antibody"+"knockout/immunoblot/immunohistochemistry"查找近期论文。*
The LPGAT1 (lysophosphatidylglycerol acyltransferase 1) antibody is a research tool used to study the function and expression of the LPGAT1 enzyme, which plays a critical role in phospholipid metabolism. LPGAT1. encoded by the *LPGAT1* gene, is an acyltransferase that catalyzes the conversion of lysophosphatidylglycerol (lyso-PG) to phosphatidylglycerol (PG), a key lipid component of cellular membranes and pulmonary surfactant. This enzyme is particularly important in maintaining mitochondrial membrane integrity and modulating lipid signaling pathways. Dysregulation of LPGAT1 has been implicated in metabolic disorders, respiratory diseases, and cancer progression.
The antibody against LPGAT1 enables the detection and quantification of the protein in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. It is typically produced using immunogens derived from recombinant LPGAT1 protein fragments or specific epitopes, yielding polyclonal or monoclonal variants. Researchers utilize this antibody to investigate LPGAT1's tissue distribution, subcellular localization, and regulatory mechanisms under physiological or pathological conditions. Validated applications often include studies in lung tissue, mitochondrial assays, and lipidomic profiling. Commercial LPGAT1 antibodies are often accompanied by knockout-validated specificity data to ensure reliability. Its development supports advancements in understanding lipid homeostasis and related therapeutic targets.
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