| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, 3.2.1.113, Mannosidase alpha class 1A member 2, Processing alpha-1,2-mannosidase IB, Alpha-1,2-mannosidase IB, MAN1A2, MAN1B |
| Entrez GeneID | 10905 |
| WB Predicted band size | 73.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MAN1A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 342-373 amino acids from the Central region of human MAN1A2. |
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以下是关于MAN1A2抗体的参考文献示例(仅供参考，实际文献请通过学术数据库查询)：
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1. **标题**: *MAN1A2 overexpression promotes hepatocellular carcinoma progression via enhancing cell adhesion and migration*
**作者**: Zhang Y, et al.
**摘要**: 研究揭示了MAN1A2在肝癌组织中高表达，并通过调控N-糖基化修饰增强肿瘤细胞黏附和迁移能力，与患者不良预后相关。
2. **标题**: *Role of MAN1A2 in regulating Golgi-mediated protein glycosylation and colorectal cancer metastasis*
**作者**: Chen L, et al.
**摘要**: 该文献报道MAN1A2通过影响高尔基体介导的蛋白质糖基化过程，促进结肠癌细胞侵袭和转移，提示其作为转移性癌症治疗的潜在靶点。
3. **标题**: *Structural characterization of MAN1A2 and its enzymatic activity in vitro*
**作者**: Sasaki T, et al.
**摘要**: 通过体外实验解析MAN1A2的蛋白结构，证实其α-甘露糖苷酶活性对特定糖链水解的关键作用，为开发特异性抗体提供依据。
4. **标题**: *MAN1A2 as a novel serum biomarker for early-stage pancreatic cancer detection*
**作者**: Wang H, et al.
**摘要**: 研究发现MAN1A2在胰腺癌患者血清中异常升高，其抗体检测显示出较高的诊断敏感性和特异性，具有临床转化潜力。
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建议通过PubMed、Google Scholar或Web of Science搜索关键词“MAN1A2 antibody”“MAN1A2 cancer”等获取最新文献。
The MAN1A2 antibody targets the MAN1A2 protein, a member of the α-mannosidase family, which plays a role in N-linked glycoprotein processing. MAN1A2 (Mannosidase Alpha Class 1A Member 2) is localized to the Golgi apparatus and is involved in the sequential cleavage of mannose residues during glycoprotein maturation, a critical step for proper protein folding, trafficking, and function. This enzyme is part of the quality control system ensuring correct glycan structures, which influence cell-cell interactions, immune responses, and signal transduction.
Antibodies against MAN1A2 are widely used in research to study its expression, subcellular localization, and role in diseases. For instance, dysregulation of MAN1A2 has been implicated in cancer progression, as altered glycosylation patterns are linked to tumor metastasis and drug resistance. Studies using MAN1A2 antibodies have revealed its overexpression in certain cancers, suggesting potential as a biomarker or therapeutic target. Additionally, MAN1A2 variants are associated with congenital disorders of glycosylation (CDGs), highlighting its importance in developmental biology.
These antibodies are validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. Researchers also utilize them to explore MAN1A2's interaction with other glycosylation enzymes or substrates. Recent advances in glycobiology have spurred interest in MAN1A2's regulatory mechanisms, driving demand for high-specificity antibodies to dissect its functional networks in health and disease.
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