Rabbit Polyclonal MTUS1 Antibody

The MTUS1 (Microtubule-Associated Tumor Suppressor 1) gene encodes a microtubule-interacting protein implicated in regulating cell proliferation, migration, and apoptosis. Initially identified as a putative tumor suppressor, MTUS1 is frequently downregulated in various cancers, including breast, lung, and colorectal carcinomas, correlating with poor prognosis. The protein exists in multiple isoforms, with the longest (MTUS1/ATIP) playing roles in microtubule stabilization, cell cycle arrest, and inhibition of angiogenesis by modulating signaling pathways like ERK and VEGF. MTUS1 antibodies are essential tools for detecting protein expression levels in research settings, particularly in studies exploring its tumor-suppressive mechanisms. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess MTUS1 localization and expression patterns in tissues or cell lines. Their application helps elucidate MTUS1's interaction with cytoskeletal components, its role in DNA damage response, and its potential as a biomarker for cancer progression. Commercially available MTUS1 antibodies are typically validated for specificity against target isoforms, though variations in isoform expression across tissues necessitate careful experimental design. Ongoing research continues to explore MTUS1's therapeutic potential, with antibodies serving as critical reagents in both mechanistic studies and diagnostic development.