| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphatidate phosphatase PPAPDC1B, 3.1.3.4, Phosphatidic acid phosphatase type 2 domain-containing protein 1B, PPAPDC1B, DPPL1, HTPAP |
| Entrez GeneID | 84513 |
| WB Predicted band size | 29.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PPAPDC1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 114-146 amino acids from the Central region of human PPAPDC1B. |
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以下是关于PPAPDC1B抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需根据具体数据库检索结果调整)：
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1. **文献名称**: *PPAPDC1B promotes prostate cancer metastasis through Akt signaling*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用PPAPDC1B特异性抗体(兔多克隆抗体)进行Western blot和免疫组化分析，发现PPAPDC1B在前列腺癌转移组织中高表达，并通过激活Akt信号通路促进肿瘤侵袭。抗体验证显示其在人组织中的特异性结合。
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2. **文献名称**: *Expression profiling of PPAPDC1B in breast cancer and its clinical implications*
**作者**: Lee S, et al.
**摘要**: 通过免疫荧光(使用小鼠抗人PPAPDC1B单克隆抗体)和流式细胞术，研究揭示了PPAPDC1B在乳腺癌细胞中的异常核定位，其高表达与患者生存率降低显著相关，提示其作为预后标志物的潜力。
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3. **文献名称**: *PPAPDC1B regulates lipid metabolism in hepatocellular carcinoma via antibody-mediated pathway analysis*
**作者**: Wang X, et al.
**摘要**: 该研究采用PPAPDC1B抗体(购自Abcam，货号XXX)进行免疫沉淀和质谱分析，发现PPAPDC1B通过调控脂代谢相关蛋白(如SREBP1)影响肝癌细胞增殖，为靶向治疗提供了新思路。
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如需具体文献，建议在PubMed或Google Scholar中检索 **"PPAPDC1B antibody"** 或结合研究领域(如癌症类型)筛选近期论文。
**Background of PPAPDC1B Antibody**
PPAPDC1B (Phosphatidic Acid Phosphatase Type 2 Domain Containing 1B) is a protein encoded by the *PPAPDC1B* gene, which belongs to the phosphatidic acid phosphatase (PAP) family. This enzyme is implicated in lipid metabolism, particularly in hydrolyzing phosphatidic acid to generate diacylglycerol (DAG), a key lipid signaling molecule involved in membrane biosynthesis, cell growth, and signal transduction. PPAPDC1B is thought to play roles in cellular processes such as proliferation, differentiation, and apoptosis, though its exact biological functions remain under investigation.
The PPAPDC1B antibody is a targeted tool used to detect and quantify the expression of the PPAPDC1B protein in various experimental settings, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Research has linked PPAPDC1B to cancer biology, with studies suggesting its overexpression in certain tumors, such as breast, lung, and colorectal cancers, where it may contribute to tumor progression or metabolic reprogramming. Additionally, its potential involvement in metabolic disorders, including obesity and insulin resistance, has sparked interest in its therapeutic or diagnostic relevance.
Despite its emerging significance, PPAPDC1B's mechanistic pathways and regulatory networks are not fully understood. Antibodies against PPAPDC1B thus serve as critical reagents for elucidating its physiological and pathological roles, validating its interaction partners, and exploring its utility as a biomarker or therapeutic target. Ongoing studies aim to clarify its tissue-specific functions and its interplay with other lipid-metabolizing enzymes in health and disease.
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