Rabbit Polyclonal PHF6 Antibody

The PHF6 (PHD finger protein 6) gene, located on the X chromosome, encodes a nucleolar protein involved in chromatin remodeling and transcriptional regulation. Mutations in PHF6 are linked to Börjeson-Forssman-Lehmann syndrome (BFLS), a rare X-linked intellectual disability disorder, and are recurrently observed in T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). PHF6 antibodies are essential tools for studying its role in these diseases, enabling detection of protein expression, localization, and interactions. Researchers use these antibodies in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to explore PHF6's regulatory functions in neurodevelopment, hematopoiesis, and tumor suppression. PHF6 is known to interact with nucleosome remodeling complexes (e.g., NuRD) and other epigenetic modifiers, influencing cell differentiation and proliferation. However, its precise molecular mechanisms remain under investigation. Commercially available PHF6 antibodies vary in specificity, requiring validation via knockout controls to ensure reliability. Dysregulation of PHF6 is associated with altered chromatin states and oncogenic pathways, highlighting its potential as a therapeutic target. Ongoing studies aim to clarify its tissue-specific roles and utility as a biomarker in malignancies.