Rabbit Polyclonal NT5M Antibody

The NT5M antibody targets NT5M (5'-nucleotidase, mitochondrial), an enzyme encoded by the NT5M gene. This enzyme catalyzes the hydrolysis of purine and pyrimidine nucleoside monophosphates, playing a role in nucleotide metabolism and mitochondrial DNA maintenance. NT5M is structurally distinct from the plasma membrane-associated CD73 (NT5E), though both share 5'-nucleotidase activity. Research has linked NT5M dysregulation to cellular stress responses, mitochondrial dysfunction, and pathologies such as cancer. In oncology, NT5M overexpression has been observed in certain malignancies, potentially influencing nucleotide salvage pathways and drug resistance. Antibodies against NT5M are primarily utilized as research tools to study its expression patterns, subcellular localization, and functional roles in disease models. Recent studies also explore its interaction with metabolic pathways and immune modulation within tumor microenvironments. Commercial NT5M antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. However, cross-reactivity with other nucleotidases remains a technical consideration. As interest grows in targeting nucleotide metabolism for cancer therapy, NT5M antibodies may gain translational relevance in diagnostic or therapeutic contexts.