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Rabbit Polyclonal PSPH(N-term) Antibody

  • 中文名: PSPH (N-term)抗体
  • 别    名: Phosphoserine phosphatase, PSP, PSPase, L-3-phosphoserine phosphatase, O-phosphoserine phosphohydrolase, PSPH
货号: IPDX33794
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000-1/8000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPhosphoserine phosphatase, PSP, PSPase, L-3-phosphoserine phosphatase, O-phosphoserine phosphohydrolase, PSPH
Entrez GeneID5723
WB Predicted band size25.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis PSPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human PSPH.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PSPH(N-terminal)抗体的3篇参考文献的简要概括:

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1. **文献名称**:*Phosphoserine phosphatase is a novel regulator of skeletal muscle metabolism*

**作者**:Smith A, et al.

**摘要**:该研究利用针对PSPH N端的特异性抗体,通过Western blot和免疫组化分析,发现PSPH在小鼠骨骼肌中的高表达及其在丝氨酸代谢中的调控作用,提示其与胰岛素信号通路的潜在关联。

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2. **文献名称**:*Targeting serine metabolism in cancer: Insights from PSPH expression profiling*

**作者**:Chen L, et al.

**摘要**:研究通过PSPH N-term抗体检测多种癌细胞系中PSPH的蛋白水平,结合代谢组学分析,揭示PSPH在肿瘤丝氨酸合成通路中的关键作用,并探讨其作为治疗靶点的潜力。

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3. **文献名称**:*Developmental regulation of PSPH in neuronal differentiation*

**作者**:Garcia R, et al.

**摘要**:使用N端特异性抗体进行免疫荧光和流式细胞术,发现PSPH在神经元分化过程中表达上调,并通过调控丝氨酸水平影响神经突触形成,为神经发育疾病提供了新机制。

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**注**:以上文献为示例性概括,实际引用需根据具体研究补充完整信息。若需精准文献,建议在PubMed或Google Scholar以关键词“PSPH antibody N-terminal”检索。

背景信息

PSPH (phosphoserine phosphatase) is a key enzyme in the serine biosynthesis pathway, catalyzing the final step where phosphoserine is dephosphorylated to produce serine. This metabolic pathway is crucial for cellular homeostasis, particularly in proliferating cells, as serine contributes to nucleotide synthesis, redox balance, and methylation reactions. Dysregulation of PSPH has been implicated in cancer, neurological disorders, and developmental defects, making it a focus of biomedical research.

The PSPH (N-term) antibody is a polyclonal or monoclonal reagent specifically designed to detect the N-terminal region of the PSPH protein. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study PSPH expression, localization, and regulation across tissues or cell lines. Researchers employ this antibody to investigate PSPH's role in tumor metabolism, as many cancers upregulate serine biosynthesis to support rapid growth. Additionally, it aids in exploring PSPH's interactions with other pathway components or regulatory proteins.

Validated for specificity and sensitivity, the PSPH (N-term) antibody helps distinguish PSPH from homologous phosphatases, reducing cross-reactivity concerns. Its application extends to both basic research and preclinical studies, particularly in contexts where serine metabolism is perturbed, such as nutrient deprivation or oncogenic stress. By enabling precise detection, this tool advances understanding of PSPH's physiological and pathological functions.

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