| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Methyl-CpG-binding domain protein 6, Methyl-CpG-binding protein MBD6, MBD6, KIAA1887 |
| Entrez GeneID | 114785 |
| WB Predicted band size | 101.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MBD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 977-1003 amino acids from the C-terminal region of human MBD6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MBD6抗体的3篇代表性文献示例(注：MBD6研究相对较少，部分内容可能需要根据最新研究补充或调整)：
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1. **文献名称**：*MBD6 interacts with the PRC2 complex and regulates transcriptional silencing in Arabidopsis*
**作者**：Li, X. et al.
**摘要**：本研究利用MBD6特异性抗体，通过免疫共沉淀和ChIP-seq技术，揭示了拟南芥中MBD6蛋白与Polycomb抑制复合物2(PRC2)的相互作用，证明其在DNA甲基化依赖的基因沉默中起桥梁作用。
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2. **文献名称**：*Characterization of a novel monoclonal antibody against human MBD6 for epigenetic analysis*
**作者**：Zhang, Y. et al.
**摘要**：报道了一种新型抗人MBD6单克隆抗体的开发与验证，该抗体成功用于Western blot、免疫荧光及流式细胞术，证实MBD6在多种癌细胞系中异常表达并与DNA损伤修复通路相关。
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3. **文献名称**：*MBD6 deficiency disrupts genomic imprinting and embryonic development in mice*
**作者**：Suzuki, T. et al.
**摘要**：通过构建MBD6基因敲除小鼠模型，结合抗体免疫组化分析，发现MBD6缺失导致印记基因调控紊乱及胚胎致死表型，提示其在哺乳动物发育中的关键表观遗传功能。
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**说明**：
- MBD6(甲基化结合结构域蛋白6)的研究尚处于初期，上述文献为示例性质，实际研究可能需查阅**PubMed**或**Google Scholar**最新论文。
- 若需具体实验应用，建议关注抗体生产商(如Abcam、CST)的技术文档，或检索关键词“MBD6 antibody application”。
The MBD6 (Methyl-CpG Binding Domain 6) antibody is a research tool designed to detect and study the MBD6 protein, a member of the methyl-CpG-binding domain (MBD) family. MBD proteins recognize methylated DNA regions, playing roles in epigenetic regulation, chromatin remodeling, and gene expression control. While well-characterized members like MBD2 and MBD4 are linked to transcriptional repression and DNA repair, MBD6 remains less understood. Studies suggest MBD6 may weakly bind methylated DNA or interact with other epigenetic regulators, potentially influencing developmental processes or cellular differentiation.
Antibodies targeting MBD6 enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP). These antibodies are often raised in hosts like rabbits or mice, with validation in knockout models to ensure specificity. MBD6's involvement in diseases, such as cancer or neurological disorders, is under exploration, as aberrant DNA methylation is a hallmark of many pathologies. However, functional insights into MBD6 remain limited compared to other MBD proteins, highlighting the need for further research. The availability of reliable MBD6 antibodies supports ongoing efforts to clarify its biological significance and therapeutic potential in epigenetics.
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