| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Activity-dependent neuroprotector homeobox protein, Activity-dependent neuroprotective protein, ADNP, ADNP1, KIAA0784 |
| Entrez GeneID | 23394 |
| WB Predicted band size | 123.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADNP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 831-860 amino acids from the C-terminal region of human ADNP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3条关于ADNP抗体的参考文献示例(内容基于模拟场景，实际文献可能需要进一步验证)：
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1. **文献名称**：*ADNP mutations lead to aberrant protein expression and neurodevelopmental deficits in autism-related syndromes*
**作者**：Oz, S., et al.
**摘要**：该研究通过ADNP特异性抗体检测，揭示了ADNP基因突变在自闭症谱系障碍患者中引起的蛋白质表达异常，并关联了其与认知功能障碍的分子机制。
2. **文献名称**：*Activity-Dependent Neuroprotective Protein (ADNP) as a biomarker in cerebrospinal fluid for neurodegenerative diseases*
**作者**：Gozes, I., et al.
**摘要**：研究开发了一种基于ADNP抗体的ELISA检测方法，发现ADNP蛋白水平在阿尔茨海默病患者的脑脊液中显著降低，提示其作为潜在生物标志物的价值。
3. **文献名称**：*ADNP interacts with microtubule-associated proteins and regulates dendritic spine formation*
**作者**：Ivashko-Pachman, Y., et al.
**摘要**：利用ADNP抗体进行免疫共沉淀和免疫荧光实验，揭示了ADNP通过调控微管动力学影响神经元突触发育的分子通路。
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注：以上文献信息为模拟示例，实际引用需以权威数据库(如PubMed)检索结果为准。建议通过关键词“ADNP antibody”或“ADNP biomarker”进一步查找最新研究。
ADNP (Activity-Dependent Neuroprotective Protein) antibodies are tools used to study the ADNP protein, a critical factor in neurodevelopment and brain function. Discovered in 1999. ADNP is highly expressed in the brain and regulates chromatin remodeling, transcriptional regulation, and synaptic plasticity. It plays a role in neuronal survival, dendritic branching, and response to oxidative stress. Mutations in the ADNP gene are linked to Helsmoortel-Van Der Aa syndrome, a rare neurodevelopmental disorder characterized by autism spectrum traits, intellectual disability, and distinct facial features. This association has driven interest in ADNP as a biomarker and therapeutic target.
ADNP antibodies enable researchers to detect, quantify, and localize the protein in tissues and cell cultures. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ADNP's expression patterns, interactions with proteins like the chromatin remodeler SWI/SNF complex, and dysregulation in disease models. Recent studies also explore ADNP's role in aging, neurodegeneration (e.g., Alzheimer’s), and cancer, broadening its biomedical relevance.
The development of high-specificity ADNP antibodies supports both basic research and clinical applications, including potential therapeutic strategies targeting ADNP pathways or correcting its dysfunction in genetic disorders.
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