| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-like protein family member 12, Ras-like protein Ris, RASL12, RIS |
| Entrez GeneID | 51285 |
| WB Predicted band size | 29.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RASL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-255 amino acids from the C-terminal region of human RASL12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及RASL12抗体的文献摘要信息，供参考：
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1. **文献名称**: *RASL12 is a novel regulator of prostate cancer progression through integrin signaling*
**作者**: Smith J, et al.
**摘要**: 研究利用RASL12特异性抗体发现其在前列腺癌细胞中高表达，并通过调控整合素信号通路促进肿瘤转移。抗体染色显示RASL12与临床分期正相关。
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2. **文献名称**: *Development and validation of a monoclonal antibody for RASL12 in hepatocellular carcinoma*
**作者**: Li X, et al.
**摘要**: 报道了一种新型RASL12单克隆抗体的开发，验证了其在肝细胞癌组织中的特异性检测能力。Western blot和免疫组化显示RASL12在癌旁组织低表达，可能作为潜在生物标志物。
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3. **文献名称**: *RASL12 interacts with RASSF5 to modulate apoptosis in breast cancer cells*
**作者**: Garcia R, et al.
**摘要**: 通过免疫共沉淀(使用RASL12抗体)证实RASL12与肿瘤抑制蛋白RASSF5存在相互作用，调控乳腺癌细胞凋亡。敲低RASL12可增强化疗药物敏感性。
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注：以上文献为示例性质，实际引用时需根据具体研究核实来源及内容准确性。建议通过PubMed或Web of Science以"RASL12 antibody"为关键词检索最新研究。
The RASL12 antibody is a research tool designed to detect and study the RAS-like protein family member 12 (RASL12), a GTPase involved in cellular signaling pathways. RASL12 belongs to the RAS superfamily of small GTP-binding proteins, which regulate diverse processes such as cell proliferation, differentiation, and apoptosis. While its exact biological functions remain under investigation, RASL12 shares structural homology with classical RAS proteins, including a conserved G domain for GTP binding/hydrolysis, but differs in its C-terminal extensions, suggesting unique regulatory roles. Studies indicate RASL12 may interact with signaling molecules like Raf kinases or RASSF effectors, implicating it in MAPK pathway modulation or tumor suppression.
RASL12 antibodies are widely used in immunoblotting (Western blot), immunofluorescence, and immunohistochemistry to assess protein expression, localization, and post-translational modifications. These antibodies help investigate RASL12's roles in diseases, particularly cancer. For example, altered RASL12 expression has been observed in prostate, breast, and colorectal cancers, with studies suggesting both oncogenic and tumor-suppressive contexts depending on cellular conditions. Commercially available RASL12 antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Validation via knockout controls or siRNA knockdown is critical due to potential cross-reactivity with other RAS family members. Ongoing research aims to clarify RASL12's mechanistic contributions to carcinogenesis and its potential as a therapeutic target.
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