| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Chymotrypsin-like elastase family member 1, Elastase-1, Pancreatic elastase 1, CELA1, ELA1 |
| Entrez GeneID | 1990 |
| WB Predicted band size | 27.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CELA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human CELA1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CELA1(N-term)抗体的3篇参考文献的简要总结(注：文献信息为模拟示例，实际引用需核实)：
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1. **文献名称**: *Characterization of a Novel Antibody Targeting the N-Terminal Domain of Human CELA1*
**作者**: Smith A, et al.
**摘要**: 该研究开发了一种针对CELA1蛋白N端表位的兔多克隆抗体，通过Western blot和免疫组化验证其特异性。结果显示抗体在胰腺组织中特异性识别CELA1.并用于研究其在慢性胰腺炎中的表达上调。
2. **文献名称**: *CELA1 Expression in Lung Fibrosis: Role of N-Terminal Epitope Recognition*
**作者**: Lee JH, et al.
**摘要**: 使用CELA1(N-term)抗体分析肺纤维化患者样本，发现CELA1在肺泡巨噬细胞中高表达，并通过ELISA证实其与疾病严重程度相关。抗体特异性通过siRNA敲低实验验证。
3. **文献名称**: *Proteolytic Activity of CELA1 in Cancer Invasion: Insights from Immunoprecipitation Studies*
**作者**: Garcia R, et al.
**摘要**: 利用抗CELA1(N-term)抗体进行免疫共沉淀实验，揭示CELA1与基质金属蛋白酶MMP-9的相互作用，促进结肠癌细胞侵袭。抗体在流式细胞术中验证了细胞表面CELA1的存在。
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建议通过PubMed或Google Scholar以关键词“CELA1 antibody N-terminal”检索最新文献，或查阅抗体供应商(如Abcam、Sigma-Aldrich)提供的引用文献列表获取具体信息。
The CELA1 (N-term) antibody is designed to target the N-terminal region of Chymotrypsin-like Elastase family member 1 (CELA1), a serine protease belonging to the elastase family. CELA1 is primarily expressed in the pancreas and plays a role in digesting dietary proteins by cleaving peptide bonds. It shares structural homology with other elastases but exhibits unique substrate specificity. The gene encoding CELA1 is located on chromosome 1 in humans, and its expression may be associated with pancreatic function and certain pathological conditions, such as pancreatitis or pancreatic cancer.
This antibody is commonly used in research to study CELA1's expression, localization, and biological roles through techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). By targeting the N-terminal region, the antibody ensures specificity, minimizing cross-reactivity with other elastase family members. Validation often includes testing on recombinant proteins or tissue samples with confirmed CELA1 expression. Researchers utilize this tool to explore CELA1's involvement in digestive disorders, tissue remodeling, and inflammation, as well as its potential as a biomarker. Commercial versions may vary in host species (e.g., rabbit, mouse) and conjugation formats (e.g., HRP, FITC), tailored for diverse experimental needs.
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